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Could male reproductive system be the main target of subchronic exposure to manganese in adult animals?
Gomes Silva, Ana Priscila; da Silva Araujo Santiago, Marcella; Maranho, Luciane Alves; de Oliveira, Rodolpho Pereira; Constantino, Dulce Helena Jardim; Pereira, Camilo Dias Seabra; da Silva, Regina Cláudia Barbosa; Perobelli, Juliana Elaine.
Afiliación
  • Gomes Silva AP; Laboratório de Toxicologia Experimental-LATOEX, Departamento de Ciências do Mar, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: anaa.bio23@gmail.com.
  • da Silva Araujo Santiago M; Laboratório de Toxicologia Experimental-LATOEX, Departamento de Ciências do Mar, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: marcellaraujoo@hotmail.com.
  • Maranho LA; Departamento de Ciências do Mar, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: lmaranho@gmail.com.
  • de Oliveira RP; Laboratório de Psicobiologia da Esquizofrenia, Departamento de Biociências, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: rodolphofb@hotmail.com.
  • Constantino DHJ; Central de laboratórios de Ciência e Tecnologia Ambiental, Universidade Sagrado Coração, USC, Bauru, SP, Brazil. Electronic address: dulcejconstantino@gmail.com.
  • Pereira CDS; Departamento de Ciências do Mar, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: camilo.seabra@unifesp.br.
  • da Silva RCB; Laboratório de Psicobiologia da Esquizofrenia, Departamento de Biociências, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: newstein@hotmail.com.
  • Perobelli JE; Laboratório de Toxicologia Experimental-LATOEX, Departamento de Ciências do Mar, Universidade Federal de São Paulo (UNIFESP), Campus Baixada Santista, Santos, SP, Brazil. Electronic address: jperobelli@gmail.com.
Toxicology ; 409: 1-12, 2018 11 01.
Article en En | MEDLINE | ID: mdl-29990519
Manganese (Mn) is one of the most common chemical elements on Earth and an essential micronutrient in animal organism. However, in supraphysiological levels and long-term exposures, it is a potential toxicant. Although nervous system is the most studied in relation to Mn toxicity, other tissues can have their function impaired by Mn in high doses. The present study investigated the possible adverse effects of subchronic exposure to supraphysiologic level of Mn (5 mg/kg or 15 mg/kg, intraperitoneally) on reproductive, neurobehavioral, renal and hepatic parameters of male rats. For the first time, the vulnerability of these parameters to Mn was concomitantly investigated. While our results demonstrate that Mn treatments were not sufficient to produce a marked effect of neurotoxic, hepatotoxic or renal toxicity in adult rats, we found typical indicators of reproductive toxicity such as histopathological changes (major in testes and epididymis) and impaired sperm concentration and quality. Mn, under these experimental conditions, seems to exert reproductive toxicity by different testicular mechanisms, i.e. direct and indirect action on germ cells. On the other hand, exposure to Mn did not change the pattern of cognitive and emotional behaviors and the histological organization of kidneys of experimental rats. The liver showed a weight increasement and hidropic degeneration, probable due to the detoxification overload. In summary, for the first time it was demonstrated that adult male reproductive system was more sensitive to Mn toxicity than nervous, hepatic and renal systems, although nervous system is known as the main target tissue of this metal.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manganeso Límite: Animals Idioma: En Revista: Toxicology Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manganeso Límite: Animals Idioma: En Revista: Toxicology Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda