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Early/prefibrotic primary myelofibrosis in patients who were initially diagnosed with essential thrombocythemia.
Kamiunten, Ayako; Shide, Kotaro; Kameda, Takuro; Ito, Masafumi; Sekine, Masaaki; Kubuki, Yoko; Hidaka, Tomonori; Akizuki, Keiichi; Tahira, Yuki; Toyama, Takanori; Kawano, Noriaki; Marutsuka, Kousuke; Maeda, Kouichi; Takeuchi, Masanori; Kawano, Hiroshi; Sato, Seiichi; Ishizaki, Junzo; Shimoda, Haruko; Yamashita, Kiyoshi; Matsuoka, Hitoshi; Shimoda, Kazuya.
Afiliación
  • Kamiunten A; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Shide K; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Kameda T; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Ito M; Japanese Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura ku, Nagoya, 453-8511, Japan.
  • Sekine M; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Kubuki Y; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Hidaka T; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Akizuki K; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Tahira Y; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Toyama T; Miyazaki Prefectural Nobeoka Hospital, 2-1-10 Shinkouji, Nobeoka, 882-0835, Japan.
  • Kawano N; Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu, Miyazaki, 880-8510, Japan.
  • Marutsuka K; Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu, Miyazaki, 880-8510, Japan.
  • Maeda K; Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo, 880-8510, Japan.
  • Takeuchi M; Koga General Hospital, 1749-1 Sudaki, Ikeuchi machi, Miyazaki, 880-0041, Japan.
  • Kawano H; Koga General Hospital, 1749-1 Sudaki, Ikeuchi machi, Miyazaki, 880-0041, Japan.
  • Sato S; Jonan Hospital, 30-5 Daioumachi, Miyakonojo, 885-0026, Japan.
  • Ishizaki J; Miyazaki Aisenkai Nichinan Hospital, 3649-2 Kazeta, Nichinan, 887-0034, Japan.
  • Shimoda H; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  • Yamashita K; Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu, Miyazaki, 880-8510, Japan.
  • Matsuoka H; Koga General Hospital, 1749-1 Sudaki, Ikeuchi machi, Miyazaki, 880-0041, Japan.
  • Shimoda K; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. kshimoda@med.miyazaki-u.ac.jp.
Int J Hematol ; 108(4): 411-415, 2018 Oct.
Article en En | MEDLINE | ID: mdl-29987745
A new entity, namely early/prefibrotic primary myelofibrosis (PMF), was introduced as a subtype of PMF in the 2016 revised World Health Organization (WHO) criteria for myeloproliferative neoplasms (MPN). It was diagnosed based on histopathological features of bone marrow (BM) biopsy specimens together with clinical parameters [leukocytosis, anemia, elevated lactate dehydrogenase (LDH) values, and splenomegaly]. The aim of this study was to evaluate the prevalence of early/prefibrotic PMF in patients who were previously diagnosed with ET, and to compare clinical features at diagnosis and outcomes between early/prefibrotic PMF and essential thrombocythemia (ET) patients. BM biopsy samples obtained at the time of ET diagnosis were available in 42 patients. Sample reevaluation according to the 2016 revised WHO criteria revealed that early/prefibrotic PMF accounted for 14% of patients who were previously diagnosed with ET, which was comparable to the rates in previous reports. Compared to patients with ET, patients with early/prefibrotic PMF had higher LDH values and higher frequencies of splenomegaly. Overall, myelofibrosis-free and acute myeloid leukemia-free survivals were comparable between the 2 groups. Accurate diagnosis is required to clarify the clinical features of Japanese ET patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mielofibrosis Primaria / Trombocitemia Esencial Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Hematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mielofibrosis Primaria / Trombocitemia Esencial Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Hematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón