Your browser doesn't support javascript.
loading
Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition.
Bucci, P; Galderisi, S; Mucci, A; Rossi, A; Rocca, P; Bertolino, A; Aguglia, E; Amore, M; Andriola, I; Bellomo, A; Biondi, M; Cuomo, A; dell'Osso, L; Favaro, A; Gambi, F; Giordano, G M; Girardi, P; Marchesi, C; Monteleone, P; Montemagni, C; Niolu, C; Oldani, L; Pacitti, F; Pinna, F; Roncone, R; Vita, A; Zeppegno, P; Maj, M.
Afiliación
  • Bucci P; Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
  • Galderisi S; Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
  • Mucci A; Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
  • Rossi A; Section of Psychiatry, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
  • Rocca P; Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy.
  • Bertolino A; Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
  • Aguglia E; Department of Clinical and Molecular Biomedicine, Psychiatry Unit, University of Catania, Catania, Italy.
  • Amore M; Section of Psychiatry, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy.
  • Andriola I; Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
  • Bellomo A; Psychiatry Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy.
  • Biondi M; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
  • Cuomo A; Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, Italy.
  • dell'Osso L; Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Favaro A; Department of Neurosciences, Psychiatric Clinic, University of Padua, Padua, Italy.
  • Gambi F; Chair of Psychiatry, Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy.
  • Giordano GM; Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
  • Girardi P; Department of Neurosciences, Mental Health and Sensory Organs, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Marchesi C; Department of Neuroscience, Psychiatry Unit, University of Parma, Parma, Italy.
  • Monteleone P; Chair of Psychiatry, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
  • Montemagni C; Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy.
  • Niolu C; Chair of Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
  • Oldani L; Department of Psychiatry, University of Milan, Milan, Italy.
  • Pacitti F; Section of Psychiatry, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
  • Pinna F; Section of Psychiatry, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
  • Roncone R; Unit of Psychiatry, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Vita A; Psychiatric Unit, School of Medicine, University of Brescia, Brescia, Italy.
  • Zeppegno P; Department of Mental Health, Spedali Civili Hospital, Brescia, Italy.
  • Maj M; Psychiatric Unit, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
Acta Psychiatr Scand ; 138(3): 253-266, 2018 09.
Article en En | MEDLINE | ID: mdl-29984409
OBJECTIVE: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. METHOD: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. RESULTS: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). CONCLUSION: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastornos del Conocimiento / Disfunción Cognitiva / Rendimiento Académico Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Psychiatr Scand Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastornos del Conocimiento / Disfunción Cognitiva / Rendimiento Académico Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Psychiatr Scand Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos