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Coupled catabolism and anabolism in autocatalytic RNA sets.
Arsène, Simon; Ameta, Sandeep; Lehman, Niles; Griffiths, Andrew D; Nghe, Philippe.
Afiliación
  • Arsène S; Laboratoire de Biochimie, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), CNRS UMR 8231 Chimie Biologie Innovation, PSL Research University, 10 rue Vauquelin, 75005 Paris, France.
  • Ameta S; Laboratoire de Biochimie, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), CNRS UMR 8231 Chimie Biologie Innovation, PSL Research University, 10 rue Vauquelin, 75005 Paris, France.
  • Lehman N; Department of Chemistry, Portland State University, P.O. Box 751, Portland, OR 97207, USA.
  • Griffiths AD; Laboratoire de Biochimie, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), CNRS UMR 8231 Chimie Biologie Innovation, PSL Research University, 10 rue Vauquelin, 75005 Paris, France.
  • Nghe P; Laboratoire de Biochimie, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), CNRS UMR 8231 Chimie Biologie Innovation, PSL Research University, 10 rue Vauquelin, 75005 Paris, France.
Nucleic Acids Res ; 46(18): 9660-9666, 2018 10 12.
Article en En | MEDLINE | ID: mdl-29982824
The ability to process molecules available in the environment into useable building blocks characterizes catabolism in contemporary cells and was probably critical for the initiation of life. Here we show that a catabolic process in collectively autocatalytic sets of RNAs allows diversified substrates to be assimilated. We modify fragments of the Azoarcus group I intron and find that the system is able to restore the original native fragments by a multi-step reaction pathway. This allows in turn the formation of catalysts by an anabolic process, eventually leading to the accumulation of ribozymes. These results demonstrate that rudimentary self-reproducing RNA systems based on recombination possess an inherent capacity to assimilate an expanded repertoire of chemical resources and suggest that coupled catabolism and anabolism could have arisen at a very early stage in primordial living systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Bacteriano / ARN Catalítico Idioma: En Revista: Nucleic Acids Res Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Bacteriano / ARN Catalítico Idioma: En Revista: Nucleic Acids Res Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido