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Plasma transferrin level correlates with the tremor-dominant phenotype of Parkinson's disease.
Si, Qian-Qian; Yuan, Yong-Sheng; Zhi, Yan; Tong, Qing; Zhang, Li; Zhang, Kezhong.
Afiliación
  • Si QQ; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Yuan YS; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zhi Y; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Tong Q; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zhang L; Department of Neurology, Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
  • Zhang K; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: kezhong_zhang1969@126.com.
Neurosci Lett ; 684: 42-46, 2018 09 25.
Article en En | MEDLINE | ID: mdl-29981876
Accumulating evidence suggests that iron metabolism may be involved in the pathophysiology of Parkinson's disease (PD), and particularly in motor phenotype. This investigation aimed to examine plasma iron metabolism related indicators in patients with tremor-dominant phenotype of PD and determine less invasive, potential markers from plasma, which could partially reflect pathophysiological mechanisms of the brain. Seventy-six PD patients were recruited and thirty-three of them were classified into the tremor-dominant PD (TD-PD) group and forty-three into the non-tremor dominant PD (NT-PD) group, as determined by clinical characteristics. Plasma iron, ceruloplasmin, transferrin and ferritin levels were measured using Beckman Coulter AU biochemical assays, immune transmission turbidimetry method, scatter turbidimetry method and chemiluminescence method, respectively. Spearman's correlation analysis and multiple linear regression analysis were used for further study. Compared to healthy controls, TD-PD patients exhibited lower plasma iron level (p = 0.006) and higher transferrin level (p < 0.001). Plasma transferrin level was much higher in the TD-PD as compared to NT-PD (p = 0.003). Furthermore, plasma transferrin level was positively correlated with the severity of tremor in TD-PD (r = 0.358, p = 0.041). Multiple linear regression further demonstrated significant associations of plasma transferrin level with severity of tremor in TD-PD (regression coefficient = 0.253, P = 0.016), independently from other confounding factors. The elevated plasma transferrin level, combining with decreased plasma iron level might be given considerable weight in the recognition of parkinsonian tremor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Fenotipo / Temblor / Transferrina Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Lett Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Fenotipo / Temblor / Transferrina Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Lett Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda