Increased virulence of an infectious bursal disease live virus vaccine after passage in chicks.
Vaccine
; 3(3): 309-12, 1985 Sep.
Article
en En
| MEDLINE
| ID: mdl-2998114
A live infectious bursal disease virus vaccine increased in virulence when passaged six times in susceptible birds, as judged by damage to the bursa of Fabricius. It is suggested that the increase in virulence of this vaccine was due to the selection of a virulent subpopulation which had been present in the vaccine since its original isolation from the field and which had not been eliminated during its attenuation by passage in cell culture. The vaccine was then plaque purified and a virus strain was selected which protected against challenge, did not damage the bursa and appeared not to passage in birds.
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01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reoviridae
/
Vacunas Virales
/
Virus de la Enfermedad Infecciosa de la Bolsa
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Países Bajos