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Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats.
Rodrigues, Joel Alves; Prímola-Gomes, Thales Nicolau; Soares, Leôncio Lopes; Leal, Tiago Ferreira; Nóbrega, Clara; Pedrosa, Danillo Laviola; Rezende, Leonardo Mateus Teixeira; Oliveira, Edilamar Menezes de; Natali, Antonio Jose.
Afiliación
  • Rodrigues JA; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Prímola-Gomes TN; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Soares LL; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Leal TF; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Nóbrega C; Universidade de São Paulo (USP), São Paulo, SP - Brazil.
  • Pedrosa DL; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Rezende LMT; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
  • Oliveira EM; Universidade de São Paulo (USP), São Paulo, SP - Brazil.
  • Natali AJ; Universidade Federal de Viçosa (UFV), Viçosa, MG - Brazil.
Arq Bras Cardiol ; 111(2): 172-179, 2018 Aug.
Article en En, Pt | MEDLINE | ID: mdl-29972415
BACKGROUND: Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. OBJECTIVE: To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). METHODS: SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. RESULTS: Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+ transients. Exercise training increased the expression of miR-214 in hypertensive rats only. CONCLUSION: The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Presión Sanguínea / Calcio / Miocitos Cardíacos / Hipertensión / Contracción Miocárdica Límite: Animals Idioma: En / Pt Revista: Arq Bras Cardiol Año: 2018 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Presión Sanguínea / Calcio / Miocitos Cardíacos / Hipertensión / Contracción Miocárdica Límite: Animals Idioma: En / Pt Revista: Arq Bras Cardiol Año: 2018 Tipo del documento: Article Pais de publicación: Brasil