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Impaired lung function in children and adolescents with Fontan circulation may improve after endurance training.
Hedlund, Eva R; Ljungberg, Henrik; Söderström, Liselott; Lundell, Bo; Sjöberg, Gunnar.
Afiliación
  • Hedlund ER; Department of Women's and Children's Health,Karolinska Institutet,Stockholm,Sweden.
  • Ljungberg H; Department of Women's and Children's Health,Karolinska Institutet,Stockholm,Sweden.
  • Söderström L; Department of Women's and Children's Health,Karolinska Institutet,Stockholm,Sweden.
  • Lundell B; Department of Women's and Children's Health,Karolinska Institutet,Stockholm,Sweden.
  • Sjöberg G; Department of Women's and Children's Health,Karolinska Institutet,Stockholm,Sweden.
Cardiol Young ; 28(9): 1115-1122, 2018 Sep.
Article en En | MEDLINE | ID: mdl-29972111
OBJECTIVES: The objective of this research was to study lung function, physical capacity, and effect of endurance training in children and adolescents after Fontan palliation compared with healthy matched controls. METHODS: Fontan patients (n=30) and healthy matched control patients (n=25) performed dynamic and static spirometry, and pulmonary diffusing capacity and maximal oxygen uptake tests, before and after a 12-week endurance training programme and at follow-up after 1 year. RESULTS: Fontan patients had a restrictive lung pattern, reduced pulmonary diffusing capacity (4.27±1.16 versus 6.61±1.88 mmol/kPa/minute, p<0.001), and a reduced maximal oxygen uptake (35.0±5.1 versus 43.7±8.4 ml/minute/kg, p<0.001) compared with controls. Patients had air trapping with a higher portion of residual volume of total lung capacity compared with controls (26±6 versus 22±5%, p<0.05). Vital capacity increased for patients, from 2.80±0.97 to 2.91±0.95 L, p<0.05, but not for controls after endurance training. The difference in diffusing capacity between patients and controls appeared to be greater with increasing age. CONCLUSIONS: Fontan patients have a restrictive lung pattern, reduced pulmonary diffusing capacity, and reduced maximal oxygen uptake compared with healthy controls. Endurance training may improve vital capacity in Fontan patients. The normal increase in pulmonary diffusing capacity with age and growth was reduced in Fontan patients, which is concerning. Apart from general health effects, exercise may improve lung function in young Fontan patients and should be encouraged.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Capacidad de Difusión Pulmonar / Tolerancia al Ejercicio / Procedimiento de Fontan / Terapia por Ejercicio / Cardiopatías Congénitas / Pulmón Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Cardiol Young Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Capacidad de Difusión Pulmonar / Tolerancia al Ejercicio / Procedimiento de Fontan / Terapia por Ejercicio / Cardiopatías Congénitas / Pulmón Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Cardiol Young Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido