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Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru.
Levy-Blitchtein, Saúl; Roca, Ignasi; Plasencia-Rebata, Stefany; Vicente-Taboada, William; Velásquez-Pomar, Jorge; Muñoz, Laura; Moreno-Morales, Javier; Pons, Maria J; Del Valle-Mendoza, Juana; Vila, Jordi.
Afiliación
  • Levy-Blitchtein S; School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, 15067, Lima, Peru.
  • Roca I; ISGlobal, Hospital Clínic - Universitat de Barcelona, 08036, Barcelona, Spain. Ignasi.roca@isglobal.org.
  • Plasencia-Rebata S; School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, 15067, Lima, Peru.
  • Vicente-Taboada W; Instituto Nacional de Enfermedades Neoplásicas, 15038, Lima, Peru.
  • Velásquez-Pomar J; Hospital Nacional Arzobispo Loayza, 15082, Lima, Peru.
  • Muñoz L; ISGlobal, Hospital Clínic - Universitat de Barcelona, 08036, Barcelona, Spain.
  • Moreno-Morales J; ISGlobal, Hospital Clínic - Universitat de Barcelona, 08036, Barcelona, Spain.
  • Pons MJ; School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, 15067, Lima, Peru.
  • Del Valle-Mendoza J; Laboratorio de Microbiología Molecular y Genética Bacteriana, Universidad Científica del Sur, Lima, Peru.
  • Vila J; School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, 15067, Lima, Peru.
Emerg Microbes Infect ; 7(1): 119, 2018 Jul 04.
Article en En | MEDLINE | ID: mdl-29970918
Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 non-duplicate clinical samples of A. baumannii collected from February 2014 through April 2016 at two tertiary care hospitals in Lima. Almost all isolates were carbapenem-resistant (97.5%), and susceptibility only remained high for colistin (95%). Pulsed-field gel electrophoresis showed two main clusters spread between both hospitals: cluster D containing 51 isolates (63.8%) associated with sequence type 2 (ST2) and carrying OXA-72, and cluster F containing 13 isolates (16.3%) associated with ST79 and also carrying OXA-72. ST2 and ST79 were endemic in at least one of the hospitals. ST1 and ST3 OXA-23-producing isolates were also identified. They accounted for sporadic hospital isolates. Interestingly, two isolates carried the novel OXA-253 variant of OXA-143 together with an upstream novel insertion sequence (ISAba47). While the predominant A. baumannii lineages in Latin America are linked to ST79, ST25, ST15, and ST1 producing OXA-23 enzymes, we report the emergence of highly resistant ST2 (IC-II) isolates in Peru producing OXA-72 and the first identification of ST3 isolates (IC-III) in Latin America, both considered a serious threat to public health worldwide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Carbapenémicos / Resistencia betalactámica / Acinetobacter baumannii Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Emerg Microbes Infect Año: 2018 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Carbapenémicos / Resistencia betalactámica / Acinetobacter baumannii Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Emerg Microbes Infect Año: 2018 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Estados Unidos