Emerging evidence for the modulation of exocytosis by signalling lipids.
FEBS Lett
; 592(21): 3493-3503, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-29962039
Membrane fusion is a key event in exocytosis of neurotransmitters and hormones stored in intracellular vesicles. In this process, soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are essential components of the exocytotic molecular machinery, while lipids have been seen traditionally as structural elements. However, the so-called signalling lipids, such as sphingosine and arachidonic acid, interact with SNAREs and directly modulate the frequency and mode of fusion events. Interestingly, recent work has proved that the sphingosine analogue FTY-720, used in the treatment of multiple sclerosis, mimics the effects of signalling lipids. In the present Review, we discuss recent investigations suggesting that endogenous signalling lipids and synthetic analogues can modulate important physiological aspects of secretion, such as quantal release, vesicle recruitment into active sites, vesicle transport and even organelle fusion in the cytosol. Therefore, these compounds are far from being merely structural components of cellular membranes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esfingosina
/
Transducción de Señal
/
Ácido Araquidónico
/
Exocitosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2018
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido