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Analysis of interventions against the liver fluke, opisthorchis viverrini.
Bürli, Christine; Harbrecht, Helmut; Odermatt, Peter; Sayasone, Somphou; Chitnis, Nakul.
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  • Bürli C; Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland. Electronic address: christine.buerli@unibas.ch.
  • Harbrecht H; Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland.
  • Odermatt P; Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland.
  • Sayasone S; Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland; Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
  • Chitnis N; Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland.
Math Biosci ; 303: 115-125, 2018 09.
Article en En | MEDLINE | ID: mdl-29958977
We adapt a population-based model of Opisthorchis viverrini transmission dynamics to determine the effectiveness of three different interventions. The model includes the definitive hosts, humans; the reservoir hosts, dogs and cats; and the intermediate hosts, snails and fish. We consider the interventions: education campaigns to reduce the consumption of raw or undercooked fish, improved sanitation and treatment through mass drug administration. We fit model parameters to a data set from two islands in southern Lao PDR. We calculate the control reproduction number, simulate different scenarios and optimise the interventions with optimal control. We look at the potential of the interventions to eliminate transmission within 20 years. The model shows that education and improved sanitation need a very high coverage to fulfil the goal of elimination, whereas annual drug distribution at medium coverage is sufficient. The best solution is a combination of drug distribution at a medium level of coverage and as high as possible coverage of education and improved sanitation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Opistorquiasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Math Biosci Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Opistorquiasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Math Biosci Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos