Your browser doesn't support javascript.
loading
Preliminary experience of sequential use of normothermic and hypothermic oxygenated perfusion for donation after circulatory death kidney with warm ischemia time over the conventional criteria - a retrospective and observational study.
Ravaioli, Matteo; De Pace, Vanessa; Comai, Giorgia; Capelli, Irene; Baraldi, Olga; D'Errico, Antonietta; Bertuzzo, Valentina Rosa; Del Gaudio, Massimo; Zanfi, Chiara; D'Arcangelo, Giovanni Liviano; Cuna, Vania; Siniscalchi, Antonio; Sangiorgi, Gabriela; La Manna, Gaetano.
Afiliación
  • Ravaioli M; Unit of General and Transplant Surgery, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • De Pace V; Unit of General and Transplant Surgery, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Comai G; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Capelli I; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Baraldi O; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • D'Errico A; Unit of Oncology and Transplant Pathology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Bertuzzo VR; Unit of General and Transplant Surgery, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Del Gaudio M; Unit of General and Transplant Surgery, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Zanfi C; Unit of General and Transplant Surgery, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • D'Arcangelo GL; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Cuna V; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Siniscalchi A; Unit of Anesthesiology, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Sangiorgi G; Emilia Romagna Transplant Reference Center, Department of Medical and Surgical Sciences, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • La Manna G; Unit of Nephrology, Dialysis and Transplantation, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola Malpighi Hospital, Bologna, Italy.
Transpl Int ; 31(11): 1233-1244, 2018 11.
Article en En | MEDLINE | ID: mdl-29957863
Donation after circulatory death (DCD) is a potential source of reducing organ demand. In Italy, DCD requires a 20-min no-touch period that prolongs warm ischemia and increases delayed graft function (DGF) risk and graft loss. We report here our preliminary experience of sequential use of normothermic regional perfusion (NRP), as standard procedure, and hypothermic oxygenated perfusion (HOPE), as an experimental technique of organ preservation, in 10 kidney transplants (KT) from five DCD Maastricht III with extensive functional warm ischemia time (fWIT) up to 325 min. During NRP, renal function tests were evaluated to accept organs which were retrieved according to standard fashion with biopsy. While waiting for pathology and cross-match results, organs were preserved with HOPE through pressure- and temperature-controlled arterial pulsatile flow. All grafts with Karpinski score ≤4 were used for conventional single KT with mean cold ischemia time of 584 ± 167 min and mean fWIT of 151 ± 132 min. At the end of HOPE, lactate levels increased significantly in all cases with DGF (P = 0.0095), which were 3/10 (30%). No primary nonfunctions were recorded, and all patients had sCr < 1.5 mg/dl at 6-month post-KT. NRP and HOPE for DCD may overcome fWIT limits safely, and lactate during HOPE predicts DGF.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de Órganos / Oxígeno / Perfusión / Isquemia Tibia Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de Órganos / Oxígeno / Perfusión / Isquemia Tibia Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza