Your browser doesn't support javascript.
loading
Synthesis and suggestion of a new nanometric gold(III) melatonin drug complex: an interesting model for testicular protection.
El-Megharbel, Samy M; Almalki, Abdulraheem Sa; Hamza, Reham Z; Gobouri, Adil A; Alhadhrami, Abdulrahman A; Al-Humaidi, Jehan Y; Refat, Moamen S.
Afiliación
  • El-Megharbel SM; Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.
  • Almalki AS; Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.
  • Hamza RZ; Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.
  • Gobouri AA; Department of Zoology, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.
  • Alhadhrami AA; Department of Biology, Faculty of Science, Taif University, Saudi Arabia.
  • Al-Humaidi JY; Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.
  • Refat MS; Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.
Future Med Chem ; 10(14): 1693-1704, 2018 07 01.
Article en En | MEDLINE | ID: mdl-29957063
AIM: Melatonin (MLT) is a major hormone secreted by the pineal gland. In this study, a gold(III) MLT (Au+3/MLT) complex has been synthesized and investigating its protective effects against testicular damage. METHODOLOGY: The structural features of the complex were investigated. For biological assessment, 30 male rats were divided into three groups for 30 days. The first control group, the second received MLT and the third received Au+3/MLT complex. RESULTS: The Au+3/MLT complex was found to be nonelectrolytic with formula (Au[MLT]2[Cl][H2O]). The ligand is monodentate and adopt square-planar geometry. Its particles range in diameter from 35 to 100 nm. MLT affords slight oxidative stress protection. The Au+3/MLT complex significantly decreases TNF-α and IL-1ß levels but elevates antioxidant enzyme capacities, reducing lipid peroxidation markers and improving testicular histological structure. CONCLUSION: The Au+3/MLT complex improves the anti-inflammatory actions of MLT, exhibits potent antioxidant activity and enhances reproductive capacity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Nanoestructuras / Complejos de Coordinación / Oro / Melatonina / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Future Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Nanoestructuras / Complejos de Coordinación / Oro / Melatonina / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Future Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido