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Premaquick© versus modified Bishop score for preinduction cervical assessment at term: A double-blind randomized trial.
Eleje, George U; Ezugwu, Euzebus C; Ugwu, Emmanuel O; Ezebialu, Ifeanyichukwu U; Eleje, Lydia I; Ojiegbe, Nnabuike O; Ajah, Leonard O; Obiora, Chukwudi C; Egeonu, Richard O; Okafor, Chigozie G; Enyinna, Perpetua K; Egede, John O; Ugochukwu, Nzubechukwu J; Asiegbu, Amarachukwu C; Ikechebelu, Joseph I.
Afiliación
  • Eleje GU; Effective Care Research Unit, Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.
  • Ezugwu EC; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  • Ugwu EO; Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria.
  • Ezebialu IU; Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria.
  • Eleje LI; Department of Obstetrics and Gynecology, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Nigeria.
  • Ojiegbe NO; Measurement and Evaluation Unit, Department of Educational Foundations, Nnamdi Azikiwe University, Awka, Nigeria.
  • Ajah LO; Department of Obstetrics and Gynecology, Federal Medical Center, Umuahia, Nigeria.
  • Obiora CC; Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria.
  • Egeonu RO; Department of Obstetrics and Gynecology, ESUT Teaching Hospital, Enugu, Nigeria.
  • Okafor CG; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  • Enyinna PK; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  • Egede JO; Department of Obstetrics and Gynecology, ESUT Teaching Hospital, Enugu, Nigeria.
  • Ugochukwu NJ; Department of Obstetrics and Gynecology, Federal Teaching Hospital, Abakaliki, Nigeria.
  • Asiegbu AC; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  • Ikechebelu JI; Department of Obstetrics and Gynecology, Federal Medical Center, Owerri, Nigeria.
J Obstet Gynaecol Res ; 44(8): 1404-1414, 2018 Aug.
Article en En | MEDLINE | ID: mdl-29956434
AIM: To test whether Premaquick biomarkers were superior to modified Bishop score for preinduction cervical assessment at term. METHODS: A multicenter, double-blind randomized clinical trial in 151 nulliparous, cephalic presenting and singleton pregnancies was conducted. The cervix was considered 'ripe' when at least two out of three Premaquick biomarkers are positive or a Bishop score of ≥6. Main outcome measures were proportion of women who were administered or had additional prostaglandin E1 analogue (PGE1) as a preinduction agent and incidence of uterine rupture. The trial was registered in PACTR registry with approval number PACTR201604001592143. Analysis was performed by intention-to-treat principle. RESULTS: The need for initial PGE1 analogue (77.6% vs 98.7%, risk ratio [RR] =0.47, 95% confidence intervals [95% CI] =0.38-0.59, P < 0.001) and additional PGE1 analogue for cervical ripening after one insertion (44.7% vs 68.0%, RR = 0.63, 95% CI = 0.46-0.86, P = 0.004) was significantly lower in Premaquick group. There was no significant difference in incidence of uterine rupture (0% vs 1.4%, RR = 0.000, P = 0.324); however, the frequency of transition to labor was statistically higher in Premaquick group (44.7% vs 22.7%, RR = 1.59, 95% CI = 1.17-2.15, P = 0.004). Interval from start of induction to any type of delivery, need for oxytocin augmentation, vaginal delivery, number of women with cesarean section for failed induction and number of infants admitted to neonatal intensive care unit were similar between the two groups (P > 0.05). CONCLUSION: Preinduction cervical assessment with Premaquick was significantly associated with higher frequency of transition to labor and reduced need for PGE1 analogue when compared to modified Bishop score. Further similar trials in other settings are necessary to strengthen or refute this observation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitócicos / Rotura Uterina / Prostaglandinas / Evaluación de Resultado en la Atención de Salud / Maduración Cervical / Trabajo de Parto Inducido / Obstetricia Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Australia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitócicos / Rotura Uterina / Prostaglandinas / Evaluación de Resultado en la Atención de Salud / Maduración Cervical / Trabajo de Parto Inducido / Obstetricia Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Australia