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Partial Depletion of Regulatory T Cells Enhances Host Inflammatory Response Against Acute Pseudomonas aeruginosa Infection After Sepsis.
Hu, Zhi-Qiang; Yao, Yong-Ming; Chen, Wei; Bian, Jia-Lan; Zhao, Lin-Jun; Chen, Long-Wang; Hong, Guang-Liang; Lu, Zhong-Qiu; Zhao, Guang-Ju.
Afiliación
  • Hu ZQ; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Yao YM; Wenzhou Key Laboratory of Emergency, Critical Care, and Disaster Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Chen W; Intensive Care Unit, Ningbo First Hospital, Ningbo, 315000, China.
  • Bian JL; Burns Institute, First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China.
  • Zhao LJ; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Chen LW; Wenzhou Key Laboratory of Emergency, Critical Care, and Disaster Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Hong GL; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Lu ZQ; Wenzhou Key Laboratory of Emergency, Critical Care, and Disaster Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Zhao GJ; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Inflammation ; 41(5): 1780-1790, 2018 Oct.
Article en En | MEDLINE | ID: mdl-29956070
Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clinical conditions was used and the potential role of Tregs in secondary Pseudomonas aeruginosa infection post-sepsis was investigated. Results showed that mice were susceptible to secondary P. aeruginosa infection 3 days, but not 7 days, post-cecal ligation and puncture (CLP). The levels of IL-17A, IL-1ß, and IL-6 remained low in CLP mice after P. aeruginosa infection, while the levels of IL-10 increased significantly. Additionally, increased number of Tregs in both lung and spleen was observed in "two-hit" mice. Injection with PC61 (anti-CD25) mAb reduced the number of Tregs by 50% in spleen and 60% in lung of septic mice. This partial depletion of Tregs elevated IL-17A, IL-1ß, and IL-6 production and decreased IL-10 levels in septic mice with P. aeruginosa infection, leading to lower bacterial load, attenuation of lung injury, and improvement of survival. The present findings demonstrate that Tregs play a crucial role in secondary P. aeruginosa infection after sepsis by modulating the inflammatory response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Pseudomonas / Linfocitos T Reguladores / Sepsis / Coinfección / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Pseudomonas / Linfocitos T Reguladores / Sepsis / Coinfección / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos