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The treatment with selenium increases placental parasitismin pregnant Wistar rats infected with the Y strain of Trypanosoma cruzi.
de Freitas, Murilo Rodrigues Barbosa; da Costa, Cássia Mariana Bronzon; Pereira, Luiz Miguel; do Prado, José Clóvis; Sala, Miguel Angel; Abrahão, Ana Amélia Carraro.
Afiliación
  • de Freitas MRB; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
  • da Costa CMB; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
  • Pereira LM; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
  • do Prado JC; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
  • Sala MA; School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
  • Abrahão AAC; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil. Electronic address: acarraro@fcfrp.usp.br.
Immunobiology ; 223(10): 537-543, 2018 10.
Article en En | MEDLINE | ID: mdl-29950281
Selenium (Se) is an essential micronutrient in the diet of mammals and has an important role in the immune function. Selenium is a key element in selenoproteins involved in the in the maintenance of the antioxidant defense. Diet with selenium is beneficial for the treatment of diseases correlated with high levels of oxidative stress, also observed in the Chagas disease. Chagas disease is a neglected disease caused by the protozoan Trypanosoma cruzi and several research groups are focused on the illness treatment. Immunomodulation of the infection using microelements is an important tool to avoid deleterious effects of the Chagas disease. Therefore, our objective was to evaluate the effects of selenium supplementation on pregnant Wistar rats infected with T. cruzi. Selenium treatment stimulated the weight and length of fetuses and placentas allied to the decrease of blood parasitemia. However, selenium demonstrated a low influence on T cells, diminishing the B cell population (CD45RA+). Moreover, the production of pro-inflammatory cytokines was downregulated under selenium administration. Low pro-inflammatory cytokines levels probably are related to the increase in the number of amastigote nests in infected and treated animals. Thus, selenium supplementation during pregnancy could impair the local placental immune response. Further studies are necessary to assess the interaction between selenium and the acute Chagas' disease during pregnancy, which will base future supplementation strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Selenio / Trypanosoma cruzi / Enfermedad de Chagas / Complicaciones Parasitarias del Embarazo / Suplementos Dietéticos Límite: Animals / Pregnancy Idioma: En Revista: Immunobiology Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Selenio / Trypanosoma cruzi / Enfermedad de Chagas / Complicaciones Parasitarias del Embarazo / Suplementos Dietéticos Límite: Animals / Pregnancy Idioma: En Revista: Immunobiology Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos