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Evidence for a Large Expansion and Subfunctionalization of Globin Genes in Sea Anemones.
Smith, Hayden L; Pavasovic, Ana; Surm, Joachim M; Phillips, Matthew J; Prentis, Peter J.
Afiliación
  • Smith HL; School of Earth, Environmental and Biological Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Pavasovic A; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Surm JM; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Phillips MJ; School of Earth, Environmental and Biological Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Prentis PJ; School of Earth, Environmental and Biological Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Genome Biol Evol ; 10(8): 1892-1901, 2018 08 01.
Article en En | MEDLINE | ID: mdl-29947797
The globin gene superfamily has been well-characterized in vertebrates, however, there has been limited research in early-diverging lineages, such as phylum Cnidaria. This study aimed to identify globin genes in multiple cnidarian lineages, and use bioinformatic approaches to characterize the evolution, structure, and expression of these genes. Phylogenetic analyses and in silico protein predictions showed that all cnidarians have undergone an expansion of globin genes, which likely have a hexacoordinate protein structure. Our protein modeling has also revealed the possibility of a single pentacoordinate globin lineage in anthozoan species. Some cnidarian globin genes displayed tissue and development specific expression with very few orthologous genes similarly expressed across species. Our phylogenetic analyses also revealed that eumetazoan globin genes form a polyphyletic relationship with vertebrate globin genes. Overall, our analyses suggest that a Ngb-like and GbX-like gene were most likely present in the globin gene repertoire for the last common ancestor of eumetazoans. The identification of a large-scale expansion and subfunctionalization of globin genes in actiniarians provides an excellent starting point to further our understanding of the evolution and function of the globin gene superfamily in early-diverging lineages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anémonas de Mar / Globinas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anémonas de Mar / Globinas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido