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Trisomy of human chromosome 21 enhances amyloid-ß deposition independently of an extra copy of APP.
Wiseman, Frances K; Pulford, Laura J; Barkus, Chris; Liao, Fan; Portelius, Erik; Webb, Robin; Chávez-Gutiérrez, Lucia; Cleverley, Karen; Noy, Sue; Sheppard, Olivia; Collins, Toby; Powell, Caroline; Sarell, Claire J; Rickman, Matthew; Choong, Xun; Tosh, Justin L; Siganporia, Carlos; Whittaker, Heather T; Stewart, Floy; Szaruga, Maria; Murphy, Michael P; Blennow, Kaj; de Strooper, Bart; Zetterberg, Henrik; Bannerman, David; Holtzman, David M; Tybulewicz, Victor L J; Fisher, Elizabeth M C.
Afiliación
  • Wiseman FK; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Pulford LJ; The LonDownS Consortium, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.
  • Barkus C; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Liao F; Department of Experimental Psychology, University of Oxford, Oxford, OX1 3PH, UK.
  • Portelius E; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA.
  • Webb R; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, S-405 30, Sweden.
  • Chávez-Gutiérrez L; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, 40507, USA.
  • Cleverley K; VIB-KU Leuven Center for Brain and Disease Research, VIB-Leuven 3000, Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, Leuven, Belgium.
  • Noy S; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Sheppard O; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Collins T; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Powell C; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Sarell CJ; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK.
  • Rickman M; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK.
  • Choong X; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Tosh JL; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Siganporia C; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Whittaker HT; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Stewart F; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.
  • Szaruga M; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA.
  • Blennow K; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, 40507, USA.
  • de Strooper B; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, S-405 30, Sweden.
  • Zetterberg H; VIB-KU Leuven Center for Brain and Disease Research, VIB-Leuven 3000, Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, Leuven, Belgium.
  • Bannerman D; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
  • Holtzman DM; UK Dementia Research Institute, London, WC2B 4AN, UK.
  • Tybulewicz VLJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, S-405 30, Sweden.
  • Fisher EMC; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Brain ; 141(8): 2457-2474, 2018 08 01.
Article en En | MEDLINE | ID: mdl-29945247
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Down / Placa Amiloide Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Brain Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Down / Placa Amiloide Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Brain Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido