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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Haraszti, Reka Agnes; Miller, Rachael; Didiot, Marie-Cecile; Biscans, Annabelle; Alterman, Julia F; Hassler, Matthew R; Roux, Loic; Echeverria, Dimas; Sapp, Ellen; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia.
Afiliación
  • Haraszti RA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Miller R; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Didiot MC; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Biscans A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Hassler MR; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Roux L; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Echeverria D; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Sapp E; Mass General Institute for Neurodegenerative Disease, Boston, MA, USA.
  • DiFiglia M; Mass General Institute for Neurodegenerative Disease, Boston, MA, USA.
  • Aronin N; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: neil.aronin@umassmed.edu.
  • Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: anastasia.khvorova@umassmed.edu.
Mol Ther ; 26(8): 1973-1982, 2018 08 01.
Article en En | MEDLINE | ID: mdl-29937418
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / ARN Interferente Pequeño / Vesículas Extracelulares / Proteína Huntingtina Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / ARN Interferente Pequeño / Vesículas Extracelulares / Proteína Huntingtina Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos