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Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.
Ravussin, Yann; Edwin, Ethan; Gallop, Molly; Xu, Lumei; Bartolomé, Alberto; Kraakman, Michael J; LeDuc, Charles A; Ferrante, Anthony W.
Afiliación
  • Ravussin Y; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Edwin E; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Gallop M; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Xu L; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Bartolomé A; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Kraakman MJ; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • LeDuc CA; Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
  • Ferrante AW; Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA. Electronic address: awf7@cumc.columbia.edu.
Cell Metab ; 28(2): 289-299.e5, 2018 08 07.
Article en En | MEDLINE | ID: mdl-29937378
Weight is defended so that increases or decreases in body mass elicit responses that favor restoration of one's previous weight. While much is known about the signals that respond to weight loss and the central role that leptin plays, the lack of experimental systems studying the overfed state has meant little is known about pathways defending against weight gain. We developed a system to study this physiology and found that overfed mice defend against increased weight gain with graded anorexia but, unlike weight loss, this response is independent of circulating leptin concentration. In overfed mice that are unresponsive to orexigenic stimuli, adipose tissue is transcriptionally and immunologically distinct from fat of ad libitum-fed obese animals. These findings provide evidence that overfeeding-induced obesity alters adipose tissue and central responses in ways that are distinct from ad libitum obesity and activates a non-leptin system to defend against weight gain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aumento de Peso / Pérdida de Peso / Tejido Adiposo / Leptina / Obesidad Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aumento de Peso / Pérdida de Peso / Tejido Adiposo / Leptina / Obesidad Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos