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Comparability of histological outcomes in rats and humans in a hernia model.
van den Hil, Leontine C L; Vogels, Ruben R M; van Barneveld, Kevin W Y; Gijbels, Marion J J; Peutz-Kootstra, Carine J; Cleutjens, Jack P M; Schreinemacher, Marc H F; Bouvy, Nicole D.
Afiliación
  • van den Hil LCL; Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. Electronic address: l.vandenhil@maastrichtuniversity.nl.
  • Vogels RRM; Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
  • van Barneveld KWY; Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
  • Gijbels MJJ; Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands; CARIM School of Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Nether
  • Peutz-Kootstra CJ; Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands; CARIM School of Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Cleutjens JPM; Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands; CARIM School of Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Schreinemacher MHF; Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Bouvy ND; Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
J Surg Res ; 229: 271-276, 2018 09.
Article en En | MEDLINE | ID: mdl-29937000
BACKGROUND: Hernia repair is one of the most frequently performed operations. In search of the ideal mesh for hernia repair, animal research is required. Although rats are most often used in experimental mesh experiments, no correlation with clinical findings in humans has ever been shown. Therefore, the aim of our study was to investigate whether adhesion formation and foreign body reactions to meshes in rats are comparable with the reactions in humans. MATERIALS AND METHODS: A fixed type of mesh was implanted intraperitoneally in a group of 10 rats and 10 patients undergoing elective, temporary stoma formation. In case of the latter, meshes were placed around the stoma. After a follow-up period of 12 wk in rats and after a median follow-up of 6 mo in humans, samples of the mesh were collected. Adhesion assessments were performed, and (immuno-) histochemical evaluation was performed by a specialized experimental pathologist and an experienced clinical pathologist. RESULTS: After the follow-up period, adhesion formation did not differ significantly between rats and humans. Moreover, general inflammation scores were comparable, although granulocytes and giant cells were more present in rats, compared with humans. On the other hand, the presence of fibrosis was more evident in humans compared with rats. CONCLUSIONS: To our knowledge, this is the first study, which showed that a specific animal model, namely a rat model, correlates with adhesion formation and the foreign body reaction to meshes in humans. It can be recommended to use rats in future experimental mesh for incisional hernia research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas / Mallas Quirúrgicas / Adherencias Tisulares / Reacción a Cuerpo Extraño / Hernia Abdominal / Modelos Animales de Enfermedad / Herniorrafia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas / Mallas Quirúrgicas / Adherencias Tisulares / Reacción a Cuerpo Extraño / Hernia Abdominal / Modelos Animales de Enfermedad / Herniorrafia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos