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Pharmacological treatment with galectin-1 protects against renal ischaemia-reperfusion injury.
Carlos, Carla P; Silva, Analice A; Gil, Cristiane D; Oliani, Sonia M.
Afiliación
  • Carlos CP; Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, Sao Paulo State University, UNESP, São José do Rio Preto, SP, Brazil.
  • Silva AA; Department of Medicine, FACERES School of Medicine, São José do Rio Preto, SP, Brazil.
  • Gil CD; Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, Sao Paulo State University, UNESP, São José do Rio Preto, SP, Brazil.
  • Oliani SM; Department of Morphology and Genetics, Federal University of Sao Paulo, UNIFESP, São Paulo, SP, Brazil.
Sci Rep ; 8(1): 9568, 2018 06 22.
Article en En | MEDLINE | ID: mdl-29934646
Galectin-1 protein (GAL-1) has important anti-inflammatory properties, but related pharmacologic approaches to effectively treat or prevent renal ischaemia and reperfusion injury are highly limited. Here, we investigated the effect of GAL-1 in a renal ischaemia-reperfusion injury rat model and an in vitro hypoxia-reoxygenation model with a proximal renal tubular epithelial cell line. In vivo, pretreatment with GAL-1 attenuated the renal parameters changed by ischaemia-reperfusion/hypoxia-reoxygenation, with recovery of renal function, protecting against influx of leukocytes, cell death and oxidative stress. Ischaemia-reperfusion/hypoxia-reoxygenation was also associated with increased renal endogenous expression of GAL-1 and intercellular adhesion molecule 1 (ICAM-1) plus augmented levels of proinflammatory cytokines IL-1ß, TNF-α and MCP-1 and decreased anti-inflammatory IL-10 in urine, all of which were abrogated by GAL-1 treatment. In vitro studies demonstrated renal tubular epithelial cells as an important source of GAL-1 during hypoxia-reoxygenation and confirmed the protective effects of exogenous GAL-1 through downregulation of proinflammatory cytokine release by proximal renal tubular epithelial cells. Collectively, our findings confirm the important anti-inflammatory role of GAL-1 in kidney ischaemia and reperfusion injury and indicate its promising use as a therapeutic approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Galectina 1 / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Galectina 1 / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido