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Can Macula and Optic Nerve Head Parameters Detect Glaucoma Progression in Eyes with Advanced Circumpapillary Retinal Nerve Fiber Layer Damage?
Lavinsky, Fabio; Wu, Mengfei; Schuman, Joel S; Lucy, Katie A; Liu, Mengling; Song, Youngseok; Fallon, Julia; de Los Angeles Ramos Cadena, Maria; Ishikawa, Hiroshi; Wollstein, Gadi.
Afiliación
  • Lavinsky F; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • Wu M; NYU Langone Eye Center, New York University School of Medicine, New York, New York; Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU School of Medicine, New York, New York.
  • Schuman JS; NYU Langone Eye Center, New York University School of Medicine, New York, New York. Electronic address: joel.schuman@nyu.edu.
  • Lucy KA; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • Liu M; Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU School of Medicine, New York, New York.
  • Song Y; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • Fallon J; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • de Los Angeles Ramos Cadena M; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • Ishikawa H; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
  • Wollstein G; NYU Langone Eye Center, New York University School of Medicine, New York, New York.
Ophthalmology ; 125(12): 1907-1912, 2018 12.
Article en En | MEDLINE | ID: mdl-29934267
PURPOSE: To evaluate the ability of OCT optic nerve head (ONH) and macular parameters to detect disease progression in eyes with advanced structural glaucomatous damage of the circumpapillary retinal nerve fiber layer (cRNFL). DESIGN: Longitudinal study. PARTICIPANTS: Forty-four eyes from 37 patients with advanced average cRNFL damage (≤60 µm) followed up for an average of 4.0 years. METHODS: All patients were examined with spectral-domain OCT and visual field (VF) assessment during at least 4 visits. MAIN OUTCOME MEASUREMENTS: Visual field mean deviation (MD) and VF index. OCT cRNFL (average, superior, and inferior quadrants), ganglion cell-inner plexiform layer (GCIPL) (average, superior, and inferior), rim area, cup volume, average cup-to-disc (C:D) ratio, and vertical C:D ratio. RESULTS: At baseline, patients had a median VF MD of -10.18 dB and mean cRNFL of 54.55±3.42 µm. The rate of change for MD and VF index were significant. No significant rate of change was noted for cRNFL, whereas significant (P < 0.001) rates were detected for GCIPL (-0.57±0.05 µm/year) and ONH parameters such as rim area (-0.010±0.001 mm2/year). CONCLUSIONS: Macula GCIPL and ONH parameters may be useful in tracking progression in patients with advanced glaucoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Células Ganglionares de la Retina / Enfermedades del Nervio Óptico / Glaucoma de Ángulo Abierto / Mácula Lútea / Fibras Nerviosas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ophthalmology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Células Ganglionares de la Retina / Enfermedades del Nervio Óptico / Glaucoma de Ángulo Abierto / Mácula Lútea / Fibras Nerviosas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ophthalmology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos