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Transcriptome analysis identifies the potential roles of long non-coding RNAs during parainfluenza virus infection.
Wu, Haoming; Yao, Ran-Ran; Yu, Shuang-Shuang; Chen, Hong-Yan; Cai, Juan; Peng, Shu-Jie; Pang, Xue-Wen; Sun, Xiu-Yuan; Zhang, Yu; Zhang, Jun.
Afiliación
  • Wu H; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Yao RR; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Yu SS; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Chen HY; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Cai J; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Peng SJ; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Pang XW; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Sun XY; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Zhang Y; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
  • Zhang J; Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology, Ministry of Health (Peking University), Peking University Health Science Center, Beijing, China.
FEBS Lett ; 592(14): 2444-2457, 2018 07.
Article en En | MEDLINE | ID: mdl-29931672
Parainfluenza virus infection is a common respiratory illness in children. Although lncRNAs are novel regulators of virus-induced innate immunity, a systemic attempt to characterize the differential expression of lncRNAs upon parainfluenza virus infection is lacking. In this report, we identify 207 lncRNAs and 166 mRNAs differentially expressed in SeV-infected HEK293T cells by microarray. The functional annotation analysis reveals that differentially regulated transcripts are predominantly involved in the host antiviral response pathway. The lncRNAs with the potential to regulate SeV-induced antiviral response are identified by building the lncRNA-mRNA coexpression network. Furthermore, silencing lncRNA ENST00000565297 results in reduced type I IFN signaling upon SeV infection. These catalogs may facilitate future analysis of the functions of lncRNAs in innate immunity and related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Paramyxoviridae / ARN Largo no Codificante / Inmunidad Innata Límite: Child / Humans Idioma: En Revista: FEBS Lett Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Paramyxoviridae / ARN Largo no Codificante / Inmunidad Innata Límite: Child / Humans Idioma: En Revista: FEBS Lett Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido