AD, adult duodenal; AEnS, adult-derived enterospheres; CLDN, claudin; CXCL, chemokine (C-X-C motif) ligand; DMEM, Dulbecco's modified Eagle medium; EGF, epidermal growth factor; Enteroids; FDR, false discovery rate; FEnS, fetal-derived enterospheres; FITC, fluorescein isothiocyanate; Fetal Organoids; HIO, human intestinal organoid; HS, Escherichia coli human commensal isolate; IFN, interferon; IL, interleukin; LPS, lipopolysaccharide A; MAMP, microbe-associated molecular pattern; NEC, necrotizing enterocolitis; NF-κB, nuclear factor-κB; Necrotizing Enterocolitis; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PGE2, prostaglandin E2; RPKM, reads per kilobase of transcript per million; RT-PCR, reverse-transcription polymerase chain reaction; TEER, transepithelial electrical resistance; TLR, Toll-like receptor; TNF, tumor necrosis factor; WAE, wound-associated epithelial cells; ΔΔCT, relative threshold cycle