Your browser doesn't support javascript.
loading
Immunological role of CD4+CD28null T lymphocytes, natural killer cells, and interferon-gamma in pediatric patients with sickle cell disease: relation to disease severity and response to therapy.
ElAlfy, Mohsen Saleh; Adly, Amira Abdel Moneam; Ebeid, Fatma Soliman ElSayed; Eissa, Deena Samir; Ismail, Eman Abdel Rahman; Mohammed, Yasser Hassan; Ahmed, Manar Elsayed; Saad, Aya Sayed.
Afiliación
  • ElAlfy MS; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Adly AAM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ebeid FSE; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Eissa DS; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ismail EAR; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. eman.ismail_70@yahoo.com.
  • Mohammed YH; Pediatrics Department, Faculty of Medicine, M.U.S.T. University, Cairo, Egypt.
  • Ahmed ME; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Saad AS; Pediatrics Department, Faculty of Medicine, M.U.S.T. University, Cairo, Egypt.
Immunol Res ; 66(4): 480-490, 2018 08.
Article en En | MEDLINE | ID: mdl-29926339
Sickle cell disease (SCD) is associated with alterations in immune phenotypes. CD4+CD28null T lymphocytes have pro-inflammatory functions and are linked to vascular diseases. To assess the percentage of CD4+CD28null T lymphocytes, natural killer cells (NK), and IFN-gamma levels, we compared 40 children and adolescents with SCD with 40 healthy controls and evaluated their relation to disease severity and response to therapy. Patients with SCD steady state were studied, focusing on history of frequent vaso-occlusive crisis, hydroxyurea therapy, and IFN-gamma levels. Analysis of CD4+CD28null T lymphocytes and NK cells was done by flow cytometry. Liver and cardiac iron overload were assessed. CD4+CD28null T lymphocytes, NK cells, and IFN-gamma levels were significantly higher in patients than controls. Patients with history of frequent vaso-occlusive crisis and those with vascular complications had higher percentage of CD4+CD28null T lymphocytes and IFN-gamma while levels were significantly lower among hydroxyurea-treated patients. CD4+CD28null T lymphocytes were positively correlated to transfusional iron input while these cells and IFN-gamma were negatively correlated to cardiac T2* and duration of hydroxyurea therapy. NK cells were correlated to HbS and indirect bilirubin. Increased expression of CD4+CD28null T lymphocytes highlights their role in immune dysfunction and pathophysiology of SCD complications.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T CD4-Positivos / Corazón / Hidroxiurea / Anemia de Células Falciformes / Antidrepanocíticos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Immunol Res Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T CD4-Positivos / Corazón / Hidroxiurea / Anemia de Células Falciformes / Antidrepanocíticos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Immunol Res Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos