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Intrapatient variability in plasma rifampicin & isoniazid in tuberculosis patients.
Kumar, A K Hemanth; Chandrasekaran, V; Kannan, T; Lavanya, J; Swaminathan, Soumya; Ramachandran, Geetha.
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  • Kumar AKH; Department of Biochemistry & Clinical Pharmacology; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
  • Chandrasekaran V; Department of Biochemistry & Clinical Pharmacology; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
  • Kannan T; Department of Biochemistry & Clinical Pharmacology; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
  • Lavanya J; District TB Officer, Chennai Corporation, Chennai, India.
  • Swaminathan S; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
  • Ramachandran G; Department of Biochemistry & Clinical Pharmacology; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
Indian J Med Res ; 147(3): 287-292, 2018 03.
Article en En | MEDLINE | ID: mdl-29923518
Background & objectives: Large variability in anti-tuberculosis (TB) drug concentrations between patients is known to exist. However, limited information is available on intrapatient drug levels during the course of anti-TB treatment (ATT). This study was conducted to evaluate intrapatient variability in plasma rifampicin (RMP) and isoniazid (INH) concentrations during ATT at start of the treatment, at the end of intensive phase (IP) of ATT and at the end of ATT in adult TB patients being treated in the Revised National TB Control Programme (RNTCP). Methods: Adult TB patients (n=485), receiving thrice-weekly ATT in the RNTCP, were studied. Two-hour post-dosing concentrations of RMP and INH were determined at month 1, end of IP and end of ATT, after directly observed drug administration. Drug concentrations were estimated by high-performance liquid chromatography. Results: The median (inter-quartile range) RMP concentrations during the first month, at end of IP and end of ATT were 2.1 (0.4-5.0), 2.4 (0.6-5.5) and 2.2 (0.5-5.3) µg/ml, respectively. The corresponding INH concentrations were 7.1 (4.2-9.9), 7.2 (3.9-10.9) and 6.7 (3.9-9.5) µg/ml. None of the differences in drug concentrations obtained at different time points during ATT were significant. RMP and INH concentrations at different time points were significantly correlated. Age and body mass index caused significant variability in drug concentrations. Interpretation & conclusions: Plasma RMP and INH estimations in adult TB patients at two hours after drug administration remained unaltered during ATT. Clinicians can consider testing drug concentrations at any time point during ATT. These findings may assume significance in the context of therapeutic drug monitoring of anti-TB drug concentrations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Tuberculosis / Isoniazida / Antituberculosos Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Indian J Med Res Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Tuberculosis / Isoniazida / Antituberculosos Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Indian J Med Res Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: India