Your browser doesn't support javascript.
loading
Genetic contribution of suppressor of cytokine signalling polymorphisms to the susceptibility to infection after traumatic injury.
Zhang, A; Gu, W; Lu, H; Zeng, L; Zhang, L; Du, D; Hao, J; Wen, D; Wang, X; Jiang, J.
Afiliación
  • Zhang A; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Gu W; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Lu H; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Zeng L; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Zhang L; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Du D; Department of Cardiothoracic Surgery, The Affiliated Central Hospital of Chongqing University, Chongqing Emergency Medical Center, Chongqing, China.
  • Hao J; Emergency Department, Kunming General Hospital, Chengdu Military of PLA, Kunming, Yunnan, China.
  • Wen D; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Wang X; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Jiang J; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Clin Exp Immunol ; 194(1): 93-102, 2018 10.
Article en En | MEDLINE | ID: mdl-29920655
Suppressor of cytokine signalling (SOCS) proteins are crucial negative regulators in many signalling pathways and are implicated in the pathogenesis of infectious diseases. The purpose of this study was to uncover possible associations of common polymorphisms within SOCS genes with infectious outcomes after traumatic injury. A total of 1087 trauma patients (Chongqing cohort 806 and Yunnan cohort 281) were recruited and followed-up for the development of infectious outcomes, such as sepsis and multiple organ dysfunction syndrome (MODS). Twelve selected single nucleotide polymorphisms (SNPs) were screened by pyrosequencing to determine their genotypes and associations with infectious complications. Among the 12 selected SNPs, only the cytokine-inducible Src homology (SH2) domain protein (CISH) promoter rs414171 polymorphism was found consistently to be associated statistically with the incidence of sepsis and MOD score in the two cohorts, despite analysing the SNPs independently or in combination. Further, patients with a T allele had significantly lower CISH expression and lower production of tumour necrosis factor (TNF)-α, but higher production of interleukin (IL)-10. Luciferase assay confirmed that the A→T variant in the rs414171 polymorphism inhibited the transcriptional activities of the CISH gene significantly. The CISH rs414171 polymorphism is associated significantly with susceptibility to sepsis and MODS in traumatic patients, which might prove to be a novel biomarker for indicating risk of infectious outcomes in critically injured patients.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heridas y Lesiones / Sepsis / Proteínas Supresoras de la Señalización de Citocinas / Insuficiencia Multiorgánica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heridas y Lesiones / Sepsis / Proteínas Supresoras de la Señalización de Citocinas / Insuficiencia Multiorgánica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido