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Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 US cities.
Barry, Vaughn; Klein, Mitchel; Winquist, Andrea; Chang, Howard H; Mulholland, James A; Talbott, Evelyn O; Rager, Judith R; Tolbert, Paige E; Sarnat, Stefanie Ebelt.
Afiliación
  • Barry V; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. vbarry@emory.edu.
  • Klein M; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Winquist A; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Chang HH; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Mulholland JA; School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
  • Talbott EO; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Rager JR; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Tolbert PE; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Sarnat SE; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
J Expo Sci Environ Epidemiol ; 29(2): 267-277, 2019 03.
Article en En | MEDLINE | ID: mdl-29915241
Although short-term exposure to ambient ozone (O3) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O3 and respiratory morbidity has not been widely investigated. We estimated the effect of daily O3 on emergency department (ED) visits for selected respiratory outcomes in 5 US cities under various model assumptions and assessed model fit. Population-weighted average 8-h maximum O3 concentrations were estimated in each city. Individual-level data on ED visits were obtained from hospitals or hospital associations. Poisson log-linear models were used to estimate city-specific associations between the daily number of respiratory ED visits and 3-day moving average O3 levels controlling for long-term trends and meteorology. Linear, linear-threshold, quadratic, cubic, categorical, and cubic spline O3 C-R models were considered. Using linear C-R models, O3 was significantly and positively associated with respiratory ED visits in each city with rate ratios of 1.02-1.07 per 25 ppb. Models suggested that O3-ED C-R shapes were linear until O3 concentrations of roughly 60 ppb at which point risk continued to increase linearly in some cities for certain outcomes while risk flattened in others. Assessing C-R shape is necessary to identify the most appropriate form of the exposure for each given study setting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Trastornos Respiratorios / Contaminantes Atmosféricos / Contaminación del Aire / Material Particulado Límite: Humans Idioma: En Revista: J Expo Sci Environ Epidemiol Asunto de la revista: EPIDEMIOLOGIA / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Trastornos Respiratorios / Contaminantes Atmosféricos / Contaminación del Aire / Material Particulado Límite: Humans Idioma: En Revista: J Expo Sci Environ Epidemiol Asunto de la revista: EPIDEMIOLOGIA / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos