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Plasma proteome changes in cord blood samples from preterm infants.
Suski, Maciej; Bokiniec, Renata; Szwarc-Duma, Monika; Madej, Józef; Bujak-Gizycka, Beata; Borszewska-Kornacka, Maria Katarzyna; Ksiazek, Teofila; Grabowska, Agnieszka; Revhaug, Cecilie; Baumbusch, Lars O; Saugstad, Ola D; Pietrzyk, Jacek Józef; Kwinta, Przemko.
Afiliación
  • Suski M; Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland. maciej.suski@uj.edu.pl.
  • Bokiniec R; Department of Neonatology and Intensive Care Warsaw Medical University, Warsaw, Poland.
  • Szwarc-Duma M; Department of Neonatology and Intensive Care Warsaw Medical University, Warsaw, Poland.
  • Madej J; Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
  • Bujak-Gizycka B; Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
  • Borszewska-Kornacka MK; Department of Neonatology and Intensive Care Warsaw Medical University, Warsaw, Poland.
  • Ksiazek T; Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Grabowska A; Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Revhaug C; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
  • Baumbusch LO; University of Oslo, Oslo, Norway.
  • Saugstad OD; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
  • Pietrzyk JJ; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
  • Kwinta P; University of Oslo, Oslo, Norway.
J Perinatol ; 38(9): 1182-1189, 2018 09.
Article en En | MEDLINE | ID: mdl-29910464
OBJECTIVE: In the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants. STUDY DESIGN: Preterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition. RESULT: Preterm delivery is associated with multiple protein abundance changes in plasma related to a plethora of processes, including inflammation and immunomodulation, coagulation, and complement activation as some key features. CONCLUSION: Plasma proteome analysis revealed numerous gestation-age-dependent protein abundance differences between term and preterm infants, which highlight key dysregulated pathways and potential new protein treatment targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Proteínas Sanguíneas / Edad Gestacional / Proteoma / Sangre Fetal Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Proteínas Sanguíneas / Edad Gestacional / Proteoma / Sangre Fetal Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos