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Advances in the use of natural receptor- or ligand-based chimeric antigen receptors (CARs) in haematologic malignancies.
Murad, Joana M; Graber, David J; Sentman, Charles L.
Afiliación
  • Murad JM; Celdara Medical LLC, Lebanon, NH, 16 Cavendish Ct Suite 240, Lebanon, NH 03766, USA. Electronic address: jm@celdaramedical.com.
  • Graber DJ; Center for Synthetic Immunity and Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, One Medical Center Dr., Lebanon, NH 03765, USA. Electronic address: david.graber@dartmouth.edu.
  • Sentman CL; Center for Synthetic Immunity and Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, One Medical Center Dr., Lebanon, NH 03765, USA. Electronic address: charles.l.sentman@dartmouth.edu.
Best Pract Res Clin Haematol ; 31(2): 176-183, 2018 06.
Article en En | MEDLINE | ID: mdl-29909918
Chimeric antigen receptors (CAR)-T cell therapy has recently made promising advances towards treatment of B-cell malignancies. This approach makes use of an antibody-derived single chain variable fragment (scFv)-based CAR to target the CD19 antigen. Currently scFvs are the most common strategy for creation of CARs, but tumor cells can also be targeted using non-antibody based approaches with designs focused on the interaction between natural receptors and their ligands. This emerging strategy has been used in unique ways to target multiple tumor types, including solid and haematological malignancies. In this review, we will highlight the performance of receptor-ligand combinations as designs for CARs to treat cancer, with a particular focus on haematologic malignancies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Neoplasias Hematológicas / Anticuerpos de Cadena Única / Antineoplásicos Inmunológicos / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Best Pract Res Clin Haematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Neoplasias Hematológicas / Anticuerpos de Cadena Única / Antineoplásicos Inmunológicos / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Best Pract Res Clin Haematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos