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Prevalence of wild type ATTR assessed as myocardial uptake in bone scan in the elderly population.
Mohamed-Salem, Laroussi; Santos-Mateo, Juan José; Sanchez-Serna, Juan; Hernández-Vicente, Álvaro; Reyes-Marle, Rafael; Castellón Sánchez, María I; Claver-Valderas, María Antonia; Gonzalez-Vioque, Emiliano; Haro-Del Moral, Francisco J; García-Pavía, Pablo; Pascual-Figal, Domingo A.
Afiliación
  • Mohamed-Salem L; Nuclear Medicine Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
  • Santos-Mateo JJ; Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
  • Sanchez-Serna J; Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
  • Hernández-Vicente Á; Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain; Facultad de Medicina, University of Murcia, Murcia, Spain. Electronic address: alvarohv@um.es.
  • Reyes-Marle R; Nuclear Medicine Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
  • Castellón Sánchez MI; Nuclear Medicine Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
  • Claver-Valderas MA; Nuclear Medicine Department, University Hospital Virgen de la Arrixaca, Murcia, Spain. Electronic address: mantonia.claver@carm.es.
  • Gonzalez-Vioque E; Clinical Biochemistry Department, Hospital Universitario Puerta del Hierro, Madrid, Spain.
  • Haro-Del Moral FJ; Clinical Biochemistry Department, Hospital Universitario Puerta del Hierro, Madrid, Spain. Electronic address: franciscojavier.haro@salud.madrid.org.
  • García-Pavía P; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta del Hierro, Madrid, Spain; Facultad de Ciencias de la Salud, University Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, Spain; CIBER Cardiovascular, Instituto de Salud Carlos III, Madri
  • Pascual-Figal DA; Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain; Facultad de Medicina, University of Murcia, Murcia, Spain; CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: dpascual@um.es.
Int J Cardiol ; 270: 192-196, 2018 Nov 01.
Article en En | MEDLINE | ID: mdl-29903517
BACKGROUND: Myocardial uptake of bone tracers has emerged as useful tool for the early detection of transthyretin amyloidosis (ATTR). The prevalence of wild-type ATTR (ATTRwt) in individuals remains to be established. METHODS: All whole body bone scans performed in individuals ≥ 75 years with no previous clinical suspicion of ATTR were revised in a population-based university hospital over a 7-year period (1509 studies corresponding to 1114 patients; 80.5 ±â€¯4.1 years, 65% males). Positive cardiac uptake was defined according to Perugini score as grade 2 or 3. Heart failure (HF) hospitalizations during the follow-up were obtained from regional administrative databases. RESULTS: Thirty-one patients ≥ 75 years (2.78%) showed cardiac uptake; compared with those without uptake, these patients were older (85 ±â€¯5 vs. 80 ±â€¯4, p < 0.001) and predominantly males (90% vs. 64%, p = 0.005). The prevalence of cardiac uptake was 3.88% in males and 0.77% in females, and increased with age, reaching 13.9% in males≥85 years (2.7% among females). The estimated prevalence for the European standard population ≥ 75 years was 4.15% in males, 1.03% in females and 2.59% in the general population. HF hospitalizations rates were 14% in patients without uptake and 29% in those with cardiac uptake (p = 0.034). After adjusting for age and gender, cardiac uptake was associated with a higher risk of HF hospitalization (OR 2.60, 95%CI 1.09-5.74, p = 0.022). CONCLUSIONS: Myocardial uptake in bone scan is very prevalent with ageing, mainly affects males and is associated with an increased risk of HF hospitalization. These findings reinforce ATTRwt as a relevant cause of HF in the elderly.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cintigrafía / Vigilancia de la Población / Radiofármacos / Neuropatías Amiloides Familiares / Corazón Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Cardiol Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cintigrafía / Vigilancia de la Población / Radiofármacos / Neuropatías Amiloides Familiares / Corazón Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Cardiol Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos