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Integrin ß1 is an essential factor in vasculogenic mimicry of human cancer cells.
Kawahara, Ryota; Niwa, Yuki; Simizu, Siro.
Afiliación
  • Kawahara R; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
  • Niwa Y; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
  • Simizu S; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Cancer Sci ; 109(8): 2490-2496, 2018 Aug.
Article en En | MEDLINE | ID: mdl-29900640
Vasculogenic mimicry (VM) formation by cancer cells is known to play a crucial role in tumor progression, but its detailed mechanism is unclear. In the present study, we focused on integrin ß1 (ITGB1) and assessed the role of ITGB1 in VM formation. We used in vitro methods to seed cancer cells on Matrigel to evaluate the capability of VM formation. We carried out ITGB1 gene deletion using the CRISPR/Cas9 system, and these ITGB1-knockout cells did not show a VM-like network formation. Further, reintroduction of ITGB1 rescued VM-like network formation in ITGB1-knockout cells. In conclusion, ITGB1 is a critical factor in VM of human cancer cells, and inhibition of ITGB1 may be a novel therapeutic approach for malignant cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina beta1 / Neovascularización Patológica Límite: Humans Idioma: En Revista: Cancer Sci Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina beta1 / Neovascularización Patológica Límite: Humans Idioma: En Revista: Cancer Sci Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido