Uncoupling the Folding and Binding of an Intrinsically Disordered Protein.

Poosapati, Anusha; Gregory, Emily; Borcherds, Wade M; Chemes, Lucia B; Daughdrill, Gary W

Poosapati, Anusha; Gregory, Emily; Borcherds, Wade M; Chemes, Lucia B; Daughdrill, Gary W.

Afiliación

Poosapati A; Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA; Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33612, USA. Electronic address: anushap@mail.usf.edu.
Gregory E; Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA; Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33612, USA. Electronic address: egregorylott@mail.usf.edu.
Borcherds WM; Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA; Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33612, USA. Electronic address: wborcher@mail.usf.edu.
Chemes LB; Instituto de Investigaciones Biotecnológicas IIB-INTECH, Universidad Nacional de San Martín, Buenos Aires, CP1650, Argentina. Electronic address: lchemes@iib.unsam.edu.ar.
Daughdrill GW; Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA; Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33612, USA. Electronic address: gdaughdrill@usf.edu.

J Mol Biol ; 430(16): 2389-2402, 2018 08 03.

Article en En | MEDLINE | ID: mdl-29890118

Asunto(s)

Proteína de Unión a CREB/química; Proteína de Unión a CREB/metabolismo; Proteínas Proto-Oncogénicas c-myb/química; Proteínas Proto-Oncogénicas c-myb/metabolismo; Sitios de Unión; Fenómenos Biofísicos; Humanos; Modelos Moleculares; Mutación; Unión Proteica; Conformación Proteica; Pliegue de Proteína; Proteínas Proto-Oncogénicas c-myb/genética; Termodinámica

Palabras clave

binding affinity; c-Myb transactivation domain; coupled folding and binding; fractional helicity; intrinsically disordered protein

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-myb / Proteína de Unión a CREB Límite: Humans Idioma: En Revista: J Mol Biol Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google