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Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass.
Loye, Ayomiposi M; Kinser, Emily R; Bensouda, Sabrine; Shayan, Mahdis; Davis, Rose; Wang, Rui; Chen, Zheng; Schwarz, Udo D; Schroers, Jan; Kyriakides, Themis R.
Afiliación
  • Loye AM; Center for Research on Interface Structures and Phenomena, Yale University, New Haven, CT, 06520, USA.
  • Kinser ER; Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.
  • Bensouda S; Center for Research on Interface Structures and Phenomena, Yale University, New Haven, CT, 06520, USA.
  • Shayan M; Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT, 06520, USA.
  • Davis R; IBM Thomas J, Watson Research Center, New York, NY, 10598, USA.
  • Wang R; Center for Research on Interface Structures and Phenomena, Yale University, New Haven, CT, 06520, USA.
  • Chen Z; Center for Research on Interface Structures and Phenomena, Yale University, New Haven, CT, 06520, USA.
  • Schwarz UD; Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.
  • Schroers J; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA.
  • Kyriakides TR; IBM Thomas J, Watson Research Center, New York, NY, 10598, USA.
Sci Rep ; 8(1): 8758, 2018 06 08.
Article en En | MEDLINE | ID: mdl-29884812
Mesenchymal stem cell (MSC) differentiation is regulated by surface modification including texturing, which is applied to materials to enhance tissue integration. Here, we used Pt57.5Cu14.7Ni5.3P22.5 bulk metallic glass (Pt-BMG) with nanopatterned surfaces achieved by thermoplastic forming to influence differentiation of human MSCs. Pt-BMGs are a unique class of amorphous metals with high strength, elasticity, corrosion resistance, and an unusual plastic-like processability. It was found that flat and nanopattened Pt-BMGs induced osteogenic and adipogenic differentiation, respectively. In addition, osteogenic differentiation on flat BMG exceeded that observed on medical grade titanium and was associated with increased formation of focal adhesions and YAP nuclear localization. In contrast, cells on nanopatterned BMGs exhibited rounded morphology, formed less focal adhesions and had mostly cytoplasmic YAP. These changes were preserved on nanopatterns made of nanorods with increased stiffness due to shorter aspect ratios, suggesting that MSC differentiation was primarily influenced by topography. These observations indicate that both elemental composition and nanotopography can modulate biochemical cues and influence MSCs. Moreover, the processability and highly tunable nature of Pt-BMGs enables the creation of a wide range of surface topographies that can be reproducibly and systematically studied, leading to the development of implants capable of engineering MSC functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Materiales Biocompatibles / Diferenciación Celular / Nanoestructuras / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Materiales Biocompatibles / Diferenciación Celular / Nanoestructuras / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido