Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in rat synaptic membranes.
Antimicrob Agents Chemother
; 27(4): 650-1, 1985 Apr.
Article
en En
| MEDLINE
| ID: mdl-2988433
Cephalosporins inhibited gamma-aminobutyric acid receptor binding in a concentration-dependent manner in vitro. Scatchard analysis revealed that cefazolin decreased the binding capacity but did not change the affinity of the receptor. It is suggested that this inhibition of gamma-aminobutyric acid receptor binding may be involved in the induction of convulsions by cephalosporins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membranas Sinápticas
/
Cefalosporinas
/
Receptores de GABA-A
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Estados Unidos