Disorder in Milk Proteins: Lactadherin Multifunctionality and Structure.

Sabha, Bassam H; Alzahrani, Fuad; Almehdar, Hussein A; Uversky, Vladimir N; Redwan, Elrashdy M

Sabha, Bassam H; Alzahrani, Fuad; Almehdar, Hussein A; Uversky, Vladimir N; Redwan, Elrashdy M.

Afiliación

Sabha BH; Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.
Alzahrani F; Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.
Almehdar HA; Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.
Uversky VN; Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.
Redwan EM; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, FL, United States.

Curr Protein Pept Sci ; 19(10): 983-997, 2018.

Article en En | MEDLINE | ID: mdl-29879884

RESUMEN

Milk fat globule membrane (MFGM) is one of the milk components that is produced by the lactating mammary glands and released to the milk in the form of vesicles. MFGM surrounds milk fat globule secreted by the milk producing cells and has a complex structure containing various lipids (e.g., triacylglycerides, phospholipids, and cholesterol), proteins and other macromolecules. Among the proteinaceous components of MFGM is lactadherin, also known as milk fat globule-EGF factor 8 protein (MFG-E8). Being one of the main proteins present in MFGM, lactadherin is related to milk secretion, has antimicrobial and antiviral effects, and plays important roles in the immune defense as one of the immune system molecules. Furthermore, lactadherin belongs to the family of secreted extracellular matrix proteins, and clearly can be considered as a multifunctional (or moonlighting) glycoprotein involved in regulation of many biological and physiological processes, such as angiogenesis, atherosclerosis, haemostasis, phagocytosis, and tissue remodeling. This review focuses on the similarities and differences of lactadherin among different species and describes the main functions of this protein, as well as its structure.

Asunto(s)

Antígenos de Superficie/metabolismo; Lactancia; Proteínas de la Leche/metabolismo; Animales; Antígenos de Superficie/química; Antígenos de Superficie/genética; Antígenos de Superficie/inmunología; Femenino; Glucolípidos/metabolismo; Glicoproteínas/metabolismo; Humanos; Proteínas Intrínsecamente Desordenadas/química; Proteínas Intrínsecamente Desordenadas/genética; Proteínas Intrínsecamente Desordenadas/inmunología; Proteínas Intrínsecamente Desordenadas/metabolismo; Gotas Lipídicas; Glicoproteínas de Membrana/química; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/inmunología; Glicoproteínas de Membrana/metabolismo; Leche/metabolismo; Proteínas de la Leche/química; Proteínas de la Leche/genética; Proteínas de la Leche/inmunología; Leche Humana/metabolismo; Polimorfismo Genético; Conformación Proteica; Especificidad de la Especie

Palabras clave

Lactadherin; MFGM; camel milk; mammary glands; milk fat globule-EGF factor 8; protein polymorphism.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia / Proteínas de la Leche / Antígenos de Superficie Límite: Animals / Female / Humans Idioma: En Revista: Curr Protein Pept Sci Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Emiratos Árabes Unidos

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