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Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice.
Dunnick, J K; Pandiri, A R; Merrick, B A; Kissling, G E; Cunny, H; Mutlu, E; Waidyanatha, S; Sills, R; Hong, H L; Ton, T V; Maynor, T; Recio, L; Phillips, S L; Devito, M J; Brix, A.
Afiliación
  • Dunnick JK; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Pandiri AR; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Merrick BA; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Kissling GE; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Cunny H; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Mutlu E; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Waidyanatha S; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Sills R; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Hong HL; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Ton TV; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Maynor T; Integrated Laboratory Systems, Research Triangle Park, NC 27709, USA.
  • Recio L; Integrated Laboratory Systems, Research Triangle Park, NC 27709, USA.
  • Phillips SL; Integrated Laboratory Systems, Research Triangle Park, NC 27709, USA.
  • Devito MJ; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
  • Brix A; EPL, Inc., Research Triangle Park, NC 27709, USA.
Toxicol Rep ; 5: 615-624, 2018.
Article en En | MEDLINE | ID: mdl-29868454
Pentabrominated diphenyl ether (PBDE) flame retardants have been phased out in Europe and in the United States, but these lipid soluble chemicals persist in the environment and are found human and animal tissues. PBDEs have limited genotoxic activity. However, in a 2-year cancer study of a PBDE mixture (DE-71) (0, 3, 15, or 50 mg/kg (rats); 0, 3, 30, or 100 mg/kg (mice)) there were treatment-related liver tumors in male and female Wistar Han rats [Crl:WI(Han) after in utero/postnatal/adult exposure, and in male and female B6C3F1 mice, after adult exposure. In addition, there was evidence for a treatment-related carcinogenic effect in the thyroid and pituitary gland tumor in male rats, and in the uterus (stromal polyps/stromal sarcomas) in female rats. The treatment-related liver tumors in female rats were unrelated to the AhR genotype status, and occurred in animals with wild, mutant, or heterozygous Ah receptor. The liver tumors in rats and mice had treatment-related Hras and Ctnnb mutations, respectively. The PBDE carcinogenic activity could be related to oxidative damage, disruption of hormone homeostasis, and molecular and epigenetic changes in target tissue. Further work is needed to compare the PBDE toxic effects in rodents and humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda