Your browser doesn't support javascript.
loading
Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia.
Asmal, Laila; Kilian, Sanja; du Plessis, Stefan; Scheffler, Frederika; Chiliza, Bonginkosi; Fouche, Jean-Paul; Seedat, Soraya; Dazzan, Paola; Emsley, Robin.
Afiliación
  • Asmal L; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Kilian S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • du Plessis S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Scheffler F; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Chiliza B; Department of Psychiatry, University of KwaZulu Natal, Durban, South Africa.
  • Fouche JP; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
  • Seedat S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Dazzan P; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Emsley R; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Schizophr Bull ; 45(2): 369-376, 2019 03 07.
Article en En | MEDLINE | ID: mdl-29860345
Schizophrenia is associated with brain connection irregularities within and between brain regions. Childhood trauma increases the risk of schizophrenia suggesting that the relationships between childhood trauma and brain connectivity requires further investigation. Here, we examine the relationship between childhood trauma (as measured by the Childhood Trauma Questionnaire) and fractional anisotropy (FA) in 54 minimally treated first-episode schizophrenia (FES) patients and 51 community matched controls. Patients who experienced high levels of trauma had significantly lower FA in the inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and inferior fronto-occipital fasciculus (IFOF) compared with controls who experienced high levels of childhood trauma. A history of childhood sexual abuse in patients was associated with lower FA in the IFOF, ILF, SLF, and forceps major compared with patients without a history of sexual abuse. However, patients who had experienced childhood emotional neglect had higher FA in the right SLF compared to patients with low levels of emotional neglect. Our findings highlight altered cortico-limbic circuitry in FES patients compared with controls and differential effects of childhood emotional neglect and sexual abuse on white matter in patients. Although stress-related white matter (WM) pathways appear to be involved in both schizophrenia and otherwise healthy controls previously exposed to childhood trauma, the pattern of disruption of WM integrity in FES patients appears to be distinct.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Abuso Sexual Infantil / Sustancia Blanca / Trauma Psicológico / Adultos Sobrevivientes de Eventos Adversos Infantiles Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Schizophr Bull Año: 2019 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Abuso Sexual Infantil / Sustancia Blanca / Trauma Psicológico / Adultos Sobrevivientes de Eventos Adversos Infantiles Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Schizophr Bull Año: 2019 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos