Your browser doesn't support javascript.
loading
The Critical Role of IL-10 in the Antineuroinflammatory and Antioxidative Effects of Rheum tanguticum on Activated Microglia.
Meng, Jie; Ni, Junjun; Wu, Zhou; Jiang, Muzhou; Zhu, Aiqin; Qing, Hong; Nakanishi, Hiroshi.
Afiliación
  • Meng J; Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Ni J; Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Wu Z; Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Jiang M; OBT Research Center, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Zhu A; Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Qing H; Institution of Geriatric, Qinghai Provincial Hospital, Xining 810007, China.
  • Nakanishi H; School of Life Science, Beijing Institute of Technology, Haidian District, Beijing 100081, China.
Oxid Med Cell Longev ; 2018: 1083596, 2018.
Article en En | MEDLINE | ID: mdl-29854069
Rheum tanguticum Maxim. ex Balf. (Rt), a traditional Tibetan medicine, is known to exert various bioactivities, including anti-inflammatory and antioxidative activities. The present study was conducted to investigate anti-inflammatory and antioxidative effects of Rt on activated microglia. Rt (10 µg/ml) significantly inhibited the mean protein level of interleukin-1ß (IL-1ß) in the organotypic hippocampal slice cultures following treatment with chromogranin A (CGA, 10 nM) and pancreastatin (10 nM), endogenous microglial activators present in senile plaques. Rt also significantly inhibited the expression and production of inflammatory and oxidative molecules, including IL-1ß, tumor necrosis factor-α, and nitric oxide, by cultured microglia after treatment with CGA. These effects of Rt are considered to be mediated by the secretion of interleukin-10 (IL-10) from microglia, because neutralizing antibodies against IL-10 significantly canceled these effects. To explore the causative components of Rt responsible for inducing the secretion of IL-10, the effects of seven components of Rt on the IL-10 expression in microglia were examined. Among them, aloe-emodin (10 µM) and (+)-catechin (30 µM) were able to induce the secretion of IL-10 from cultured microglia. Therefore, aloe-emodin and (+)-catechin are deemed responsible for the antineuroinflammatory and antioxidative effects of Rt through the secretion of IL-10 from microglia. Accordingly, Rt is considered potentially useful for the treatment of AD.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rheum / Interleucina-10 / Microglía / Antiinflamatorios / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rheum / Interleucina-10 / Microglía / Antiinflamatorios / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos