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Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy.
Chauhan, Deepak S; Arunkumar, P; Prasad, Rajendra; Mishra, Sumit Kumar; K Reddy, B Pradeep; De, Abhijit; Srivastava, Rohit.
Afiliación
  • Chauhan DS; Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay, Powai, Mumbai, India.
  • Arunkumar P; Centre for Research in Nanotechnology and Science (CRNTS), Indian Institute of Technology Bombay, Powai, Mumbai, India.
  • Prasad R; Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay, Powai, Mumbai, India.
  • Mishra SK; Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India.
  • K Reddy BP; Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay, Powai, Mumbai, India.
  • De A; Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India. Electronic address: ade@actrec.gov.in.
  • Srivastava R; Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay, Powai, Mumbai, India. Electronic address: rsrivasta@iitb.ac.in.
Mater Sci Eng C Mater Biol Appl ; 90: 539-548, 2018 Sep 01.
Article en En | MEDLINE | ID: mdl-29853123
We demonstrate facile and green synthesis of gold deposited zein nanoshells (AuZNS) using environmental benign solvent ethanol. Water soluble glycol chitosan is used for stabilization as well as for cationic functionalization of zein nanoparticles. Gold deposition is performed via ex-situ method at ambient conditions. AuZNS is of size around 100 nm and shows high inertness and biocompatibility even at double the therapeutic dosage. The absorbance is tuned at 808 nm for imaging-guided plasmonic photothermal therapy of cancer. Highly effective killing of cancer cells irrespective of their chemorefractory status is noticed at a very low therapeutic dosage of 25 µg and 5 min of biologically acceptable (500 mW) 808 nm laser irradiation. AuZNS also exhibit better X-ray attenuation in comparison to the commercially available iodine based contrast agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zeína / Nanopartículas del Metal / Nanocáscaras / Oro Límite: Animals / Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zeína / Nanopartículas del Metal / Nanocáscaras / Oro Límite: Animals / Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos