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Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord.
Kononenko, Olga; Mityakina, Irina; Galatenko, Vladimir; Watanabe, Hiroyuki; Bazov, Igor; Gerashchenko, Anna; Sarkisyan, Daniil; Iatsyshyna, Anna; Yakovleva, Tatiana; Tonevitsky, Alex; Marklund, Niklas; Ossipov, Michael H; Bakalkin, Georgy.
Afiliación
  • Kononenko O; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address: Olga.kononenko@farmbio.uu.se.
  • Mityakina I; Moscow State University, Moscow, Russia.
  • Galatenko V; Moscow State University, Moscow, Russia; Tauber Bioinformatics Research Center, University of Haifa, Haifa, Israel.
  • Watanabe H; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Bazov I; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Gerashchenko A; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, Kiev, Ukraine.
  • Sarkisyan D; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Iatsyshyna A; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Department of Human Genetics, Institute of Molecular Biology and Genetics, Kiev, Ukraine.
  • Yakovleva T; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Tonevitsky A; Moscow State University, Moscow, Russia; Higher School of Economics, Moscow, Russia.
  • Marklund N; Department of Clinical Sciences, Division of Neurosurgery, University Hospital of Southern Sweden, Lund University, Lund, Sweden.
  • Ossipov MH; Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ, United States.
  • Bakalkin G; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address: Georgy.bakalkin@farmbio.uu.se.
Brain Res ; 1695: 78-83, 2018 09 15.
Article en En | MEDLINE | ID: mdl-29852138
The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pain model. Effects of the left- and right-side SNL on expression of EOS genes in the ipsi- and contralateral spinal domains were analysed. The SNL-induced changes were complex and different between the genes; between the dorsal and ventral spinal domains; and between the left and right sides of the spinal cord. Prodynorphin (Pdyn) expression was upregulated in the ipsilateral dorsal domains by each the left and right-side SNL, while changes in expression of µ-opioid receptor (Oprm1) and proenkephalin (Penk) genes were dependent on the SNL side. Changes in expression of the Pdyn and κ-opioid receptor (Oprk1) genes were coordinated between the ipsi- and contralateral sides. Withdrawal response thresholds, indicators of mechanical allodynia correlated negatively with Pdyn expression in the right ventral domain after right side SNL. These findings suggest multiple roles of the EOS gene products in spinal sensitization and changes in motor reflexes, which may differ between the left and right sides.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Expresión Génica / Péptidos Opioides / Analgésicos Opioides / Neuralgia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Expresión Génica / Péptidos Opioides / Analgésicos Opioides / Neuralgia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos