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An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules.
Woll, Kellie A; Guzik-Lendrum, Stephanie; Bensel, Brandon M; Bhanu, Natarajan V; Dailey, William P; Garcia, Benjamin A; Gilbert, Susan P; Eckenhoff, Roderic G.
Afiliación
  • Woll KA; Department of Anesthesiology and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
  • Guzik-Lendrum S; Department of Biological Sciences and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
  • Bensel BM; Department of Biological Sciences and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
  • Bhanu NV; Department of Biochemistry and Biophysics, Epigenetics Program, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
  • Dailey WP; Department of Chemistry, University of Pennsylvania School of Arts and Sciences, Philadelphia, Pennsylvania 19104.
  • Garcia BA; Department of Biochemistry and Biophysics, Epigenetics Program, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
  • Gilbert SP; Department of Biological Sciences and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
  • Eckenhoff RG; Department of Anesthesiology and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104. Electronic address: roderic.eckenhoff@uphs.upenn.edu.
J Biol Chem ; 293(29): 11283-11295, 2018 07 20.
Article en En | MEDLINE | ID: mdl-29844014
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propofol / Cinesinas / Anestésicos Intravenosos / Sitio Alostérico / Microtúbulos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propofol / Cinesinas / Anestésicos Intravenosos / Sitio Alostérico / Microtúbulos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos