Oxaliplatin and irinotecan induce heterogenous changes in the EMT markers of metastasizing colorectal carcinoma cells.

Skarkova, Veronika; Kralova, Vera; Krbal, Lukas; Matouskova, Petra; Soukup, Jiri; Rudolf, Emil

Skarkova, Veronika; Kralova, Vera; Krbal, Lukas; Matouskova, Petra; Soukup, Jiri; Rudolf, Emil.

Afiliación

Skarkova V; Department of Medical Biology and Genetics, Faculty of Medicine, Charles University, Simkova 870, Hradec Králové CZ-500 38, Czech Republic. Electronic address: hanusovav@lfhk.cuni.cz.
Kralova V; Department of Medical Biology and Genetics, Faculty of Medicine, Charles University, Simkova 870, Hradec Králové CZ-500 38, Czech Republic.
Krbal L; The Fingerland Department of Pathology, Faculty of Medicine and Faculty Hospital in Hradec Kralove, Charles University, Sokolská 581, Hradec Kralove CZ-500 05, Czech Republic.
Matouskova P; Department of Biochemical Sciences, Faculty of Pharmacy In Hradec Králové, Charles University, Heyrovského 1203, Hradec Králové CZ-500 05, Czech Republic.
Soukup J; The Fingerland Department of Pathology, Faculty of Medicine and Faculty Hospital in Hradec Kralove, Charles University, Sokolská 581, Hradec Kralove CZ-500 05, Czech Republic.
Rudolf E; Department of Medical Biology and Genetics, Faculty of Medicine, Charles University, Simkova 870, Hradec Králové CZ-500 38, Czech Republic.

Exp Cell Res ; 369(2): 295-303, 2018 08 15.

Article en En | MEDLINE | ID: mdl-29842879

Asunto(s)

Antineoplásicos/farmacología; Neoplasias Colorrectales/tratamiento farmacológico; Transición Epitelial-Mesenquimal/efectos de los fármacos; Irinotecán/farmacología; Oxaliplatino/farmacología; Adenocarcinoma/tratamiento farmacológico; Adenocarcinoma/metabolismo; Adenocarcinoma/secundario; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Línea Celular Tumoral; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/patología; Resistencia a Antineoplásicos; Humanos; Metástasis Linfática; Invasividad Neoplásica; Neovascularización Patológica

Palabras clave

ABCATP binding cassette; CRCColorectal cancer; Drug resistance; EMTEpithelial-mesenchymal transition; Epithelial-mesenchymal transition; ITIrinotecan; Irinotecan; MRPMultidrug resistance-associated protein; Metastatic colon cancer; OPTOxaliplatin; Oxaliplatin; Primary cell lines

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Transición Epitelial-Mesenquimal / Irinotecán / Oxaliplatino / Antineoplásicos Límite: Humans Idioma: En Revista: Exp Cell Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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