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Prevalence and distribution of HPV genotypes and cervical-associated lesions in sexually active young French women following HPV vaccine.
Bretagne, C H; Jooste, V; Guenat, D; Riethmuller, D; Bouvier, A M; Bedgedjian, I; Prétet, J L; Valmary-Degano, S; Mougin, C.
Afiliación
  • Bretagne CH; Service d'Anatomie et cytologie pathologiques, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: bretagne.charleshenri@gmail.com.
  • Jooste V; Registre Bourguignon des Cancers Digestifs, Hôpital Universitaire Dijon-Bourgogne, 21000 Dijon, France; INSERM, U1231, EPICAD Team, Université Bourgogne-Franche-Comté, 21000 Dijon, France. Electronic address: valerie.jooste@u-bourgogne.fr.
  • Guenat D; EA 3181, UFR SMP, Université Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, rue Ambroise Paré, 25000 Besançon, France; Centre National de Référence Papillomavirus, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: david.guenat@univ-fcomte.fr.
  • Riethmuller D; EA 3181, UFR SMP, Université Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, rue Ambroise Paré, 25000 Besançon, France; Service de gynécologie obstétrique, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: didier.riethmuller@univ-fcomte.fr.
  • Bouvier AM; Registre Bourguignon des Cancers Digestifs, Hôpital Universitaire Dijon-Bourgogne, 21000 Dijon, France; INSERM, U1231, EPICAD Team, Université Bourgogne-Franche-Comté, 21000 Dijon, France. Electronic address: anne-marie.bouvier@u-bourgogne.fr.
  • Bedgedjian I; Service d'Anatomie et cytologie pathologiques, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: ibedgedjian@chu-besancon.fr.
  • Prétet JL; EA 3181, UFR SMP, Université Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, rue Ambroise Paré, 25000 Besançon, France; Centre National de Référence Papillomavirus, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: jean_luc.pretet@univ-fcomte.fr.
  • Valmary-Degano S; Service d'Anatomie et cytologie pathologiques, CHU Besançon, Bd Fleming, 25000 Besançon, France; EA 3181, UFR SMP, Université Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, rue Ambroise Paré, 25000 Besançon, France. Electronic address: severine.valmary@univ-fcomte.fr.
  • Mougin C; EA 3181, UFR SMP, Université Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, rue Ambroise Paré, 25000 Besançon, France; Centre National de Référence Papillomavirus, CHU Besançon, Bd Fleming, 25000 Besançon, France. Electronic address: christiane.mougin@univ-fcomte.fr.
J Gynecol Obstet Hum Reprod ; 47(10): 525-531, 2018 Dec.
Article en En | MEDLINE | ID: mdl-29807205
BACKGROUND: Despite the availability of safe and effective HPV vaccines in France, more than 80% of girls remain unvaccinated. SETTING: A regional university hospital referral center in France. OBJECTIVE: To estimate the overall prevalence and distribution of HPV in vaccinated, sexually active young French women who were screened for cervical cancer by cytology and HPV testing. METHODS: High-risk HPV (HR-HPV) prevalence, genotype-specific prevalence and extent of multiple infections were assessed in 125 cervical samples from females with available vaccine data using hc2 assay and INNO-LiPA assay. HPV status was analyzed in accordance with cytological data. RESULTS: In our series, mean age was 23 years, overall prevalence of HR-HPV was 52% and was correlated with the lesion grade. The diversity of HPV genotypes was broad. Single HR-HPV infections were identified in 11%, 21% and 47% of women with NILM, ASC-US/-H and LSIL respectively. Multiple infections with HR-HPV were detected in 28% of the specimens. Only 24.5% of women with NILM presented infections with 2 genotypes or more, vs 28% of women with ASC-US/-H and 35% of women with LSIL. The overall prevalence of genotypes covered by the quadrivalent vaccine was low (5.9%); with 4.2%, 0%, 0.8% and 0.8% for HPV 16, HPV 18, HPV 6 and HPV 11 respectively. CONCLUSION: Among HPV-vaccinated young women, HR-HPV are detected at a high rate, and an association with the grade of cytological abnormalities was observed. However, HPV 16 and 18, both targeted by the vaccines, are remarkably rare among young French women since program implementation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Infecciones por Papillomavirus / Papillomavirus Humano 6 / Papillomavirus Humano 11 / Papillomavirus Humano 16 / Papillomavirus Humano 18 / Vacunas contra Papillomavirus Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: Europa Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2018 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Infecciones por Papillomavirus / Papillomavirus Humano 6 / Papillomavirus Humano 11 / Papillomavirus Humano 16 / Papillomavirus Humano 18 / Vacunas contra Papillomavirus Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: Europa Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2018 Tipo del documento: Article Pais de publicación: Francia