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Renal iron deposition by magnetic resonance imaging in pediatric ß-thalassemia major patients: Relation to renal biomarkers, total body iron and chelation therapy.
ElAlfy, Mohsen Saleh; Khalil Elsherif, Nayera Hazaa; Ebeid, Fatma Soliman Elsayed; Ismail, Eman Abdel Rahman; Ahmed, Khaled Aboulfotouh; Darwish, Yasser Wagih; Ibrahim, Ahmed Samir; Elghamry, Islam Reda Farag; Shokrey, Nermeen Adel; Alajeil, Dunia Naser.
Afiliación
  • ElAlfy MS; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Khalil Elsherif NH; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: nayeraelsherif@med.asu.edu.eg.
  • Ebeid FSE; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ismail EAR; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ahmed KA; Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Darwish YW; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ibrahim AS; Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Elghamry IRF; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Shokrey NA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Alajeil DN; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eur J Radiol ; 103: 65-70, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29803388
BACKGROUND: The reciprocal of multiecho gradient-echo (ME-GRE) T2* magnetic resonance imaging (MRI) R2*, rises linearly with tissue iron concentration in both heart and liver. Little is known about renal iron deposition in ß-thalassemia major (ß-TM). AIM: To assess renal iron overload by MRI and its relation to total body iron and renal function among 50 pediatric patients with ß-TM. METHODS: Serum ferritin, serum cystatin C, urinary albumin creatinine ratio (UACR), and urinary ß2-microglobulin (ß2 M) were measured with calculation of ß2 M/albumin ratio. Quantification of liver, heart and kidney iron overload was done by MRI. RESULTS: Serum cystatin C, UACR and urinary ß2 microglobulin as well as urinary ß2m/albumin were significantly higher in ß-TM patients than the control group. No significant difference was found as regards renal R2* between Patients with mean serum ferritin above 2500 µg/L and those with lower serum cutoff. Renal R2* was higher in patients with poor compliance to chelation therapy and positively correlated to indirect bilirubin, LDH, cystatin C and LIC but inversely correlated to cardiac T2*. CONCLUSION: kidney iron deposition impairs renal glomerular and tubular functions in pediatric patients with ß-TM and is related to hemolysis, total body iron overload and poor compliance to chelation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Terapia por Quelación / Talasemia beta / Sobrecarga de Hierro / Hígado Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2018 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Terapia por Quelación / Talasemia beta / Sobrecarga de Hierro / Hígado Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2018 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Irlanda