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Matrix metalloproteinase 7, soluble Fas and Fas ligand serum levels for predicting docetaxel resistance and survival in castration-resistant prostate cancer.
Szarvas, Tibor; Sevcenco, Sabina; Módos, Orsolya; Keresztes, Dávid; Nyirády, Péter; Csizmarik, Anita; Ristl, Robin; Puhr, Martin; Hoffmann, Michèle J; Niedworok, Christian; Hadaschik, Boris; Maj-Hes, Agnieszka; Shariat, Shahrokh F; Kramer, Gero.
Afiliación
  • Szarvas T; Department of Urology, Semmelweis University, Budapest, Hungary.
  • Sevcenco S; Department of Urology, Vienna General Hospital, Medical University Vienna, Vienna, Austria.
  • Módos O; Department of Urology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
  • Keresztes D; Department of Urology, Vienna General Hospital, Medical University Vienna, Vienna, Austria.
  • Nyirády P; Department of Urology, Semmelweis University, Budapest, Hungary.
  • Csizmarik A; Department of Urology, Semmelweis University, Budapest, Hungary.
  • Ristl R; Department of Urology, Semmelweis University, Budapest, Hungary.
  • Puhr M; Department of Urology, Semmelweis University, Budapest, Hungary.
  • Hoffmann MJ; Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
  • Niedworok C; Experimental Urology, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
  • Hadaschik B; Department of Urology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Maj-Hes A; Department of Urology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
  • Shariat SF; Department of Urology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
  • Kramer G; Department of Urology, Vienna General Hospital, Medical University Vienna, Vienna, Austria.
BJU Int ; 122(4): 695-704, 2018 10.
Article en En | MEDLINE | ID: mdl-29802777
OBJECTIVE: To assess the predictive value of pre-chemotherapy matrix metalloproteinase 7 (MMP-7), soluble Fas (sFas) and Fas ligand (FasL) serum levels, as well as their changes during therapy. PATIENTS AND METHODS: Serum levels of MMP-7, Fas and FasL were determined by ELISA in 96 patients with castration-resistant prostate cancer (CRPC): 21 docetaxel-resistant patients who received one single series and 75 docetaxel-sensitive patients who received repeated series of docetaxel. In addition to the 96 pretreatment serum samples, 987 sera collected during chemotherapy were also analysed. RESULTS: Higher pretreatment serum MMP-7, sFas and prostate-specific antigen (PSA) levels were significantly associated with both docetaxel resistance (P = 0.007, P = 0.001, P < 0.001, respectively) and shorter cancer-specific survival (P < 0.001, P = 0.041, P < 0.001, respectively). High MMP-7 level remained an independent predictor of both docetaxel resistance (hazard ratio [HR] 2.298, 95% confidence interval [CI]: 1.354-3.899; P = 0.002) and poor cancer-specific survival (HR 2.11, 95% CI: 1.36-3.30; P = 0.001) in multivariable analyses. Greater increase in MMP-7 levels in the second treatment holiday and greater increase in PSA levels in the first and second treatment holidays were predictive of survival. CONCLUSIONS: Pretreatment serum MMP-7 levels may help to select patients with CRPC who are likely to benefit from docetaxel chemotherapy. Furthermore, MMP-7 levels alone or in combination with PSA levels could be used for therapy monitoring. Correlative studies embedded in clinical trials are necessary to validate these biomarkers for clinical decision-making.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Metaloproteinasa 7 de la Matriz / Proteína Ligando Fas / Neoplasias de la Próstata Resistentes a la Castración / Docetaxel / Antineoplásicos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Metaloproteinasa 7 de la Matriz / Proteína Ligando Fas / Neoplasias de la Próstata Resistentes a la Castración / Docetaxel / Antineoplásicos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido