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Drug-induced keratin 9 interaction with Hsp70 in bladder cancer cells.
Andolino, C; Hess, C; Prince, T; Williams, H; Chernin, M.
Afiliación
  • Andolino C; Biology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA.
  • Hess C; Biology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA.
  • Prince T; Department of Urology, Geisinger Clinic, Danville, PA, USA.
  • Williams H; Department of Urology, Geisinger Clinic, Danville, PA, USA.
  • Chernin M; Biology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA. chernin@bucknell.edu.
Cell Stress Chaperones ; 23(5): 1137-1142, 2018 09.
Article en En | MEDLINE | ID: mdl-29802537
A pull-down experiment (co-immunoprecipitation) was performed on a T24 human bladder cancer cell lysate treated with the Hsp inhibitor VER155008 using an Hsp70 antibody attached to Dynabeads. Keratin 9, a cytoskeleton intermediate filament protein, was identified by LC MS/MS analysis. This novel finding was confirmed by Western blotting, RT-PCR, and immunocytochemistry. Other members of the keratin family of proteins have been shown to be involved in cancer progression, most recently identified to be associated with cell invasion and metastasis. The specific role of keratin 9 expression in these cells is yet to be determined.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Proteínas HSP70 de Choque Térmico / Queratina-9 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Stress Chaperones Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Proteínas HSP70 de Choque Térmico / Queratina-9 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Stress Chaperones Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos