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Rationale and Methodology of the SARAH Trial: Long-Term Cardiovascular Outcomes in Patients With Resistant Hypertension and Obstructive Sleep Apnea.
Sapiña-Beltrán, Esther; Torres, Gerard; Martínez-Alonso, Montserrat; Sánchez-de-la-Torre, Manuel; Franch, Maria; Bravo, Carmen; Masa, Juan F; Felez, Miquel; Fortuna-Gutierrez, Ana Maria; Abad, Jorge; García-Río, Francisco; Drager, Luciano F; Lee Chi-Hang, Ronald; Martínez-García, Miguel Ángel; Barbé, Ferran; Dalmases, Mireia.
Afiliación
  • Sapiña-Beltrán E; Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRBLleida, Lleida, Cataluña, Spain.
  • Torres G; Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRBLleida, Lleida, Cataluña, Spain.
  • Martínez-Alonso M; University of Lleida, IRBLleida, Biostatistics Unit, Lleida, Cataluña, Spain.
  • Sánchez-de-la-Torre M; Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRBLleida, Lleida, Cataluña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
  • Franch M; Hospital Santa Maria, Internal medicine department, Lleida, Cataluña, Spain.
  • Bravo C; Hospital Santa Maria, Internal medicine department, Lleida, Cataluña, Spain.
  • Masa JF; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Hospital San Pedro de Alcantara, Respiratory Dept, Caceres, Extremadura, Spain.
  • Felez M; Hospital del Mar, Unit of Sleep Breathing Disorders, Respiratory Dept, Barcelona, Cataluña, Spain.
  • Fortuna-Gutierrez AM; Hospital de la Santa Creu i Sant Pau, Respiratory Dept, Barcelona, Cataluña, Spain.
  • Abad J; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Hospital Universitari Germans Trias i Pujol, Respiratory Dept, Badalona, Cataluña, Spain.
  • García-Río F; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Hospital Universitario La Paz-IdiPAZ, Respiratory Dept, Madrid, Spain.
  • Drager LF; University of São Paulo Medical School, Heart Institute(InCor), Sao Paulo, Brazil.
  • Lee Chi-Hang R; National University Heart Centre Singapore, Department of Cardiology, Singapore.
  • Martínez-García MÁ; Hospital Universitario y Politécnico La Fe, Respiratory Department, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
  • Barbé F; Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRBLleida, Lleida, Cataluña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
  • Dalmases M; Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRBLleida, Lleida, Cataluña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Electronic address: mdalmases.lleida.ics@gencat.cat.
Arch Bronconeumol (Engl Ed) ; 54(10): 518-523, 2018 Oct.
Article en En, Es | MEDLINE | ID: mdl-29801678
INTRODUCTION: Patients with resistant hypertension (RH) have a high risk of developing cardiovascular events; therefore, new therapeutic approaches to better control blood pressure may be useful in improving cardiovascular outcomes. The prevalence of obstructive sleep apnea (OSA) is very high among patients with RH. Continuous positive airway pressure (CPAP) has been shown to be an effective treatment for reducing blood pressure in patients with RH. Nevertheless, the long-term effect of CPAP treatment on cardiovascular outcomes has not been explored. The main objective of the SARAH study is to assess the impact of OSA and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with RH. METHODS: This study is a multi-center, prospective, observational cohort study. A total of 1371 patients with RH will be enrolled in the study and followed once a year for five years. At inclusion, ambulatory blood pressure monitoring (ABPM) and a sleep study will be performed in all subjects. Socio-demographic, clinical and cardiovascular variables will be collected at baseline and follow-up. Subsequently, subjects with OSA will be managed according to local standard practice. Based on the OSA diagnosis and its treatment, three cohorts of subjects with RH will be defined: non-OSA, treated OSA and non-treated OSA. CONCLUSIONS: This study will contribute to elucidating the long-term impact of OSA treatments on blood pressure control and cardiovascular outcomes in patients with RH. These results will contribute to improve the cardiovascular prognosis of patients with RH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Vasoespasmo Coronario / Apnea Obstructiva del Sueño / Hipertensión Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En / Es Revista: Arch Bronconeumol (Engl Ed) Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Vasoespasmo Coronario / Apnea Obstructiva del Sueño / Hipertensión Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En / Es Revista: Arch Bronconeumol (Engl Ed) Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: España