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[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. / Éffektivnost' semaksa pri lechenii bol'nykh na raznykh stadiiakh ishemicheskogo insul'ta.
Gusev, E I; Martynov, M Yu; Kostenko, E V; Petrova, L V; Bobyreva, S N.
Afiliación
  • Gusev EI; Pirogov Russian National Research Medical University, Ministry of Health of Russiа, Moscow, Russia.
  • Martynov MY; Pirogov Russian National Research Medical University, Ministry of Health of Russiа, Moscow, Russia.
  • Kostenko EV; Pirogov Russian National Research Medical University, Ministry of Health of Russiа, Moscow, Russia; Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia.
  • Petrova LV; Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia.
  • Bobyreva SN; Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 118(3. Vyp. 2): 61-68, 2018.
Article en Ru | MEDLINE | ID: mdl-29798983
AIM: To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS). MATERIAL AND METHODS: One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined. All patients were divided into early (89±9 days) and late (214±22 days) rehabilitation groups. Each group was subdivided into semax+ and semax- subgroups. Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval. Plasma BDNF levels, motor performance on the British Medical Research Council scale and Barthel index were assessed in all groups. RESULTS: Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period. In semax- subgroups high BDNF plasma levels were positively correlated with early rehabilitation. Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index. There was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement. The correlation between BDNF plasma levels and Barthel score was modified by the timing of rehabilitation. CONCLUSION: Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Isquemia Encefálica / Hormona Adrenocorticotrópica / Accidente Cerebrovascular / Rehabilitación de Accidente Cerebrovascular Límite: Aged / Female / Humans / Male / Middle aged Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Isquemia Encefálica / Hormona Adrenocorticotrópica / Accidente Cerebrovascular / Rehabilitación de Accidente Cerebrovascular Límite: Aged / Female / Humans / Male / Middle aged Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia